Novel 1,3-Dimethyl-5-propionylpyrimidine-2,4,6(1H,3H,5H)-trione was synthesized and recrystallized from ethanol. The compound was characterized by 1H NMR, 13C NMR in CDCl3, DMSO-d6 and acetone-d6, elemental analysis and X-ray diffraction. The NMR data observed that the title compound exists in the enol tautomer rather than keto, and it stabilized by strong H-bond as observed form the NMR data a...

The use of high-throughput screening allowed for the optimization of reaction conditions for the palladium-catalyzed asymmetric decarboxylative alkylation reaction of enolate-stabilized enol carbonates. Changing to a non-polar reaction solvent and to an electron-deficient PHOX derivative as ligand from our standard reaction conditions improved the enantioselectivity for the alkylation of a keta...

In previous publications we reported abundant empirical evidence of the spontaneous oscillatory transenantiomerization of optically pure enantiomeric 2-arylpropionic acids (2-APAs), resulting in a racemic mixture of the pairs of enantiomers. Our experiments were performed with 2phenylpropionic acid, ibuprofen, and naproxen. The last two compounds are non-steroidal anti-inflammatory drugs (NSAID...

It has recently been reported that aluminum plays a very important role in reducing the activity of Krebs-cycle enzymes and glutamate dehydrogenase in rat brain homogenate. Therefore, it is necessary to identify the aluminum binding ability with the pivotal substrate alpha-ketoglutarate in biological systems. The interactions of aluminum with alpha-ketoglutarate were studied with pH-potentiomet...

The usefulness of thin-layer chromatography (TLC) as an efficient measuring technique in the studies of oscillatory trans-enantiomerization of profens from the S to the R configuration (and vice versa) during their storage as 70% ethanol solutions is demonstrated in the literature. S-(+)-ibuprofen, S-(+)-naproxen, and S,R-(+/-)-2-phenylpropionic acid are utilized as the test profens. It is prov...

The effect of tautomerism on the mismatch discrimination was studied on 7-deazapurine and 8-aza-7-deazapurine analogues of isoguanosine. 7-Halogenated 7-deaza-2'-deoxyisoguanosines show better base pair discrimination than 2'-deoxyisoguanosine due to the more favored keto tautomer formation. 8-Aza-7-deazaisoguanosine and its 7-halogeno derivatives also show higher keto tautomer population than ...

The idea of the enol form of nucleotides being responsible for the formation of some noncanonical pairs was put forward by Watson and Crick in their first paper on DNA structure [1]. In the context of this hypothesis, the GU pair may contain either the enol form of uracil and the keto form of guanine or the enol form of guanine and the keto form of uracil. Later, in 1966, Francis Crick proposed...

Complexes of Ni(II) (1), Cu(II) (2) and Cd(II) (3) with a novel Schiff base N-(2-2-[1-(3aminophenyl) ethylidene] hydrazino-2-oxoethyl) benzamide (LH) have been prepared and characterized by elemental analysis, TG-DTA, magnetic, electronic, molar conductivity measurements, IR, SEM, NMR, ESR and mass studies. It is observed that all the complexes having 1:1 metal-ligand stoichiometry are tetracoo...

Dynamic chirality of iminoresorcin[4]arenes that originates from regioselective and diastereoselective keto-enol tautomerisation was switched by non-covalent interactions with achiral molecules, as demonstrated by experimental electronic circular dichroism (ECD) spectra supported by TD DFT calculations.