In the original study of 2-keto-3-deoxy-6-phosphogluconic aldolase (I), and in subsequent experiments, the net synthesis of 2-keto-3-deoxy-6-phosphogluconate from the cleavage products could not be demonstrated. The present experiments were undertaken to clarify this point and to test the conformity of the reaction catalyzed by 2-keto-3-deoxy-6-phosphogluconic aldolase to the general characteri...

A proposed structure for schizocommunin (Z)-1(hydroxy) and its geometric isomer (E)-1(hydroxy), which exist in a keto form, has been synthesized. However, the spectroscopic data of (Z)-1(keto) and (E)-1(keto) were not consistent with those reported for natural schizocommunin. After reinvestigating the spectral data for natural schizocommunin, we synthesized the quinazolinone derivative (Z)-2 as...

A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide alpha-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide alpha-ketoacids with unprotected side chains is reported.

In the title compound, C(25)H(23)N(3)O(3)S, an intra-molecular N-H⋯O inter-action generates an S(6) ring, which stabilizes the enamine-keto form of the compound. This S(6) ring and the pyrazole ring are essentially coplanar, making a dihedral angle of 1.49 (6)°. The bond lengths within the S(6) ring of the mol-ecule lie between classical single- and double-bond lengths, indicating extensive con...

Introduction Conclusions References

DFT-based modeling as well as experimental examination of model keto nucleosides have revealed that high susceptibility of these compounds to acids is due to formation of intermediate cyclonucleoside cations of low energy. Theoretically established chemical structures of these previously overlooked intermediates explain the reaction courses for a cluster of nucleoside reactions.

Exploiting light to drive redox reactions is currently a hot topic since considered as an environmentally friendly source of energy. Consequently, cyanobacteria, which can use e.g., for generating NADPH, are in the focus research. Previously, it has been shown that various heterologous enzymes could be expressed these microorganisms. Here we demonstrated successful inducer-free expression α-ket...

a series of 1,3-dipolar cycloaddition reactions are carried out using cyclodimers of simple nitrones and various dipolarophiles; substituted isoxazolidines are isolated and identified. it is proved that such cyclodimers, in solution, are in equilibrium with their corresponding nitrones and enamines. it is also concluded that aldocyclodimers are more potent than keto-cyclodimers in establishing ...

The reductive amination/cyclization of biomass-based keto acids and amines to lactams under mild condition with ammonia borane (NH3–BH3) as the hydrogen donor in absence additives is reporte...