نتایج جستجو برای: keratin

تعداد نتایج: 6076  

Journal: :Mechanisms of Development 2001
Stacy Mazzalupo Pierre A Coulombe

We report the developmental regulation of a lacZ reporter transgene fused to the promoter region of the human keratin 6a gene. In mouse embryos, the transgene is expressed in the periderm (the outermost layer of embryonic epidermis), as are the endogenous keratin 6 alpha and beta genes. A subset of periderm cells, localized to temporary epithelial fusions, is known to contain keratin 6 protein,...

Journal: :Methods in enzymology 2016
Nicole Schwarz Marcin Moch Reinhard Windoffer Rudolf E Leube

Keratin filaments are a hallmark of epithelial differentiation. Their cell type-specific spatial organization and dynamic properties reflect and support epithelial function. To study this interdependency, imaging of fluorescently tagged keratins is a widely used method by which the temporospatial organization and behavior of the keratin intermediate filament network can be analyzed in living ce...

Journal: :The Annals of occupational hygiene 2004
Yi-Chun E Chao Leena A Nylander-French

Chemical contaminants or their metabolites may bind to and react with keratin proteins in the stratum corneum of the skin. Here, we present a tape-stripping method for the removal and quantification of keratin from the stratum corneum for normalization of extracted concentrations of naphthalene (as a marker for jet fuel exposure) from 12 human volunteers before and after exposure to jet fuel (J...

Journal: :The Journal of Cell Biology 1998
Elizabeth Hutton Rudolph D. Paladini Qian-Chun Yu Mei Yen Pierre A. Coulombe Elaine Fuchs

Dividing populations of stratified and simple epithelial tissues express keratins 5 and 14, and keratins 8 and 18, respectively. It has been suggested that these keratins form a mechanical framework important to cellular integrity, since their absence gives rise to a blistering skin disorder in neonatal epidermis, and hemorrhaging within the embryonic liver. An unresolved fundamental issue is w...

2015
D. I. Zheleva

Keratin and collagen are ones of the most abundant proteins which can be used in a variety of biomedical application due to their biocompatibility and biodegradability. Even though, keratin and collagen biomaterials are very high potential for tissue engineering applications. But, the major disadvantages of the natural biomolecules are their poor mechanical properties. Therefore it must be modi...

Journal: :Histology and histopathology 2009
Angelika Alonso Uwe Ikinger Jürgen Kartenbeck

The keratins, members of the intermediate filament family, are characteristically expressed in epithelial cells. In the various types of epithelia, the keratin expression pattern is characterized by cell-type specific combinations of the keratin isotypes with a plain pattern in monolayered (simple) epithelia and more complex patterns in stratified and pseudostratified epithelia. Here we demonst...

Journal: :The Journal of Cell Biology 1987
K H Kim V Stellmach J Javors E Fuchs

We report here the discovery that retinoids are potent regulators of epithelial morphology and keratin expression in cultured human mesothelial cells. When LP-9 cells are cultured in medium supplemented with vitamin A-depleted serum, they grow with an extreme spindle-shaped morphology and synthesize abundant levels of vimentin, but very little keratin. When retinoic acid is added to the medium ...

Journal: :Genes & development 1987
P M Mathisen L Miller

To determine the mechanism of action of the thyroid hormone triiodothyronine (T3) during metamorphosis of the amphibian epidermis, we have investigated the developmental activation of the 63-kD keratin genes in the frog Xenopus laevis. These genes code for three closely related keratins that first appear in the larval epidermis and accumulate during metamorphosis to become the most abundant pro...

2013
Anna Akinshina Etienne Jambon-Puillet Patrick B Warren Massimo G Noro

BACKGROUND Keratins are important structural proteins found in skin, hair and nails. Keratin Intermediate Filaments are major components of corneocytes, nonviable horny cells of the Stratum Corneum, the outermost layer of skin. It is considered that interactions between unstructured domains of Keratin Intermediate Filaments are the key factor in maintaining the elasticity of the skin. RESULTS...

Journal: :The Journal of Cell Biology 1983
M W Klymkowsky R H Miller E B Lane

The organization of intermediate filaments in cultured epithelial cells was rapidly and radically affected by intracellularly injected monoclonal antikeratin filament antibodies. Different antibodies had different effects, ranging from an apparent splaying apart of keratin filament bundles to the complete disruption of the keratin filament network. Antibodies were detectable within cells for mo...

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