Spinal and bulbar muscular atrophy (Kennedy disease) is an X-linked, adult-onset motor neuron disease characterized by slow, progressive weakness of the extremity muscles with CAG triplet repeat expansion in androgen receptor gene. Hirayama (HD) juvenile onset asymmetric amyotrophy hand most common males Asia. We report a patient atypical Kennedy presenting typical HD.

Phosphatidylethanolamine (PE) is an important inner membrane phospholipid mostly synthesized de novo via the PE-Kennedy pathway and by the decarboxylation of phosphatidylserine. CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) catalyzes the formation of CDP-ethanolamine, which is often the rate regulatory step in the PE-Kennedy pathway. In the current investigation, we show that the reduced...

Postpartum depression with a prevalence of 10–15% (Gavin et al. 2005) is characterized by social retreat, feelings of hopelessness and guilt as well as the inability to feel gratification in the mother’s role. A combined treatment of postpartum depression with antidepressant psychopharmacotherapy and psychotherapy is to be preferred in moderate to severe depressive episodes and is the choice of...

A. Gifford, K. Zackowski, J. Wang, P. C. van Zijl, G. Raymond, and S. Smith Department of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD, United States, Motion Analysis Laboratory, Kennedy Krieger Institute, Baltimore, MD, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore,...

A. Gifford, A. Binstock, J. Wang, K. Zackowski, J. Farrell, P. C. van Zijl, G. Raymond, and S. Smith Department of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD, United States, University of Maryland School of Medicine, Baltimore, MD, Motion Analysis Laboratory, Kennedy Krieger Institute, Baltimore, MD, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, M...

Bronskill, P., Kennedy, T. D. & Lane, B. G. (1972) Biochim. Biophys. Acta 262,275-282 Dunn, D. B. (1963) Biochem. J. 8 6 , 1 4 ~ 1 5 ~ Dunn, D. B. & Flack, I. H. (1967) Abstr. FEBS Meet. 4th pp. 82 Dunn, D. B. & Flack, I. H. (1970) John Innes Institute Annual Report 61,7678 Fissekis, J. D. & Sweet, F. (1970) Biochemistry 9, 3136-3142 Gray, M. W. & Lane, B. G. (1968) Biochemistry 7,3441-3453 Ken...