The systematic approach to pharmacologic treatment is typically to begin with the safest, simplest, and most conservative measures. It has been realized that the more rapidly inflammation is under control, the less likely it is that there will be permanent sequelae. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of initial treatment for inflammation. In addition, the slow-acting...

Systemic juvenile idiopathic arthritis (JIA) is an autoinflammatory condition that is distinct from other forms of childhood arthritis. Recently, biologic agents that specifically inhibit the cytokines interleukin (IL)-1 and IL-6 have demonstrated remarkable clinical effectiveness and confirmed the importance of these cytokines in the disease process. Future studies are likely to optimize the c...

[Purpose] The aim of this study was to assess patients' health-related quality of life, compare it with a healthy age-matched population, and examine associations between functional ability and quality of life among juvenile rheumatoid arthritis (JRA) patients. [Subjects and Methods] The study participants were 26 JRA patients and 25 controls. The Childhood Health Assessment Questionnaire and t...

OBJECTIVE To compare polysomnography (PSG) and self-reported sleep, symptoms (pain and fatigue), and anxiety between children with active and inactive juvenile rheumatoid arthritis (JRA) and examine relations among sleep, symptoms, and anxiety. METHODS Two consecutive nights of PSG, self-reported sleep, and symptoms were obtained in 70 children 6-11 years of age with active (n = 35) or inacti...

Examined direct and mediated relations between condition parameters and maternal mental health for 53 mothers of 2- to 11-year-old children with juvenile rheumatoid arthritis (JRA). Multivariate analyses revealed that when considered simultaneously, indices of both biological severity and functional severity were associated significantly with maternal mental health. Further, mother's appraisals...

In the preceding paper (Bywaters, Carter, and Scott, 1959), it was shown that the Rose-Waaler test (positive in about 50 to 70 per cent. of adult rheumatoid arthritis cases) is frequently negative in childhood arthritis (Still's disease). This has also been remarked by others (Pike, Sulkin, and Coggeshall, 1955; Alexander and de Forest, 1954; Ziff, 1957), although by the inhibition technique 95...

183 Received August 5, 2015; revised and accepted September 17, 2015. Published online October 17, 2015; doi: 10.1620/tjem.237.183. Correspondence: Yingjie Zhong, Department of Pediatrics, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Erdao District, Changchun 130031, China. e-mail: [email protected] Blueberry Improves the Therapeutic Effect of Etanercept on Patient...

Introduction All chronic childhood arthritides of unknown aetiology are termed as Juvenile Idiopathic Arthritis ( JIA). The disease may occur as early as 3–6 years of age, but it occasionally manifests before one year of age. JIA is the most common chronic rheumatic disease in childhood with an incidence of 10-19/100.000 children under the age of 16 years, and it is a major cause of physically ...

A substantial amount of work has gone into elucidating the non-HLA genetic associations in JRA. In this paper, we attempt to provide an overview of this body of knowledge. Direct comparison of the different studies is difficult. Different ethnic populations, different JRA/JIA subgroups, and different systems of nomenclature and classification all impose various limitations. Adding to the comple...

OBJECTIVE To study trends in the incidence of juvenile rheumatoid arthritis (JRA). METHODS The study covered subjects who were entitled under the nation-wide sickness insurance scheme to receive specially reimbursed medication for juvenile rheumatic diseases in 11 of 21 central hospital districts in Finland (the base population comprised about 445,000 children <16 yr of age) in 1995. Data fro...