نتایج جستجو برای: jsi
تعداد نتایج: 145 فیلتر نتایج به سال:
JSI-124, also known as cucurbitacin I, is a selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3), and in vitro and in vivo studies have found that it has anti-tumor and anti-proliferative properties. However, the role of JSI124 in tumor-associated B cells has yet to be elucidated. The present study demonstrated that STAT3 is significantly activated ...
Myeloid-derived suppressor cells (MDSCs) represent heterogeneous immunosuppressive cells in multiple cancer types and display potent immunosuppressive activity on T cells. We have shown the increased expression of IDO in breast cancer. Because IDO plays a pivotal role in immune tolerance via suppressing T cell function, the aim of this study was to investigate the expression of IDO in MDSCs in ...
PURPOSE To develop a liquid chromatography/mass spectrometry (LC-MS) method for the quantitative analysis of cucurbitacin I (JSI-124), an anti-cancer inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway, in rat plasma samples. METHODS Standard samples of cucurbitacin I were prepared from a stock solution (1 mg/mL) in methanol. Inter...
Extensive job stress and workload are main causes of frustration and reduced efficiency among workers and despite negative effects of these factors on employees' performance, related studies in rehabilitation staff are limited. The aim of this study was to evaluate job stress, workload and their related factors in rehabilitation staff. In this cross-sectional study, 150 employees in three rehab...
زمینه و هدف: تصاویر تشدید مغناطیسی به دلیل قدرت تفکیک پذیری خیلی خوبی که برای بافت های نرم و غیر نرم در بدن انسان دارد، در موارد بسیار زیادی برای کمک در تشخیص و درمان تومور مغز مورد استفاده قرار می گیرد. روش بررسی: روش پیشنهادی مبتنی بر یک روش بدون ناظر است که ناحیه تومور را با آنالیز شباهت دو نیمکره کشف می کند. این آنالیز، تصویر یک تابع هدف که مبتنی بر ضریب bhattacharyya است را محاسبه می کند ک...
The reconstruction of the information contaminated by cloud and cloud shadow is an important step in pre-processing of high-resolution satellite images. The cloud and cloud shadow automatic segmentation could be the first step in the process of reconstructing the information contaminated by cloud and cloud shadow. This stage is a remarkable challenge due to the relatively inefficient performanc...
Background: Magnetic resonance imaging (MRI) is widely applied for examination and diagnosis of brain tumors based on its advantages of high resolution in detecting the soft tissues and especially of its harmless radiation damages to human bodies. The goal of the processing of images is automatic segmentation of brain edema and tumors, in different dimensions of the magnetic resonance images. M...
extensive job stress and workload are main causes of frustration and reduced efficiency among workers and despite negative effects of these factors on employees' performance, related studies in rehabilitation staff are limited. the aim of this study was to evaluate job stress, workload and their related factors in rehabilitation staff. in this cross-sectional study, 150 employees in three ...
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