Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic joint inflammation. The precise aetiology of this autoimmune process remains unclear. Soluble factors produced by infiltrating synovial cells play an important role in driving the inflammatory process that leads to inflammatory cell migration and proliferation in the synovial tissue. These soluble factors consist mainly...

BACKGROUND The relationship between lung and joint inflammation in rheumatoid arthritis is poorly understood. Lung inflammation with resultant protein citrullination may trigger anti-citrullinated protein antibodies, inflammation, and arthritis. Alternatively, lung and joint inflammation may be two manifestations of a single underlying pathology. The lung has increased citrullination and TNF-α ...

Frequent monitoring of rheumatoid arthritis (RA) patients enables timely treatment adjustments and improved outcomes. Currently this is not feasible due to a shortage of rheumatologists. An optical spectral transmission device is presented for objective assessment of joint inflammation in RA patients, while improving diagnostic accuracy and clinical workflow. A cross-sectional, nonrandomized ob...

Introduction The presence of joint inflammation in juvenile idiopathic arthritis (JIA) patients can be made by physical examination and confirmed by imaging. The discrepancy between physical examination and MRI for evaluation of synovitis in a target joint is possibly explained by the fact that clinical measures mostly reflect overall disease activity instead of measures specific for the joint ...

Rheumatoid arthritis is an inflammatory condition characterized by overzealous inflammation that leads to joint damage and is associated with an increased incidence of cardiovascular disease. Statins are frontline therapeutics for patients with cardiovascular disease and exert beneficial actions in rheumatoid arthritis. The mechanism that mediates the beneficial actions of statins in rheumatoid...

The rheumatoid arthritis is one of the most prevalent feeling incomidity and sever pain in the joint of the knee among individuals whom it is considered as the weakner illness, because of decisive being undistiguished its cause of beginning illness, severe pain, long trip, and its destructive role. The different treatments are considered to cease or retard this illness process but what it appea...

The rheumatoid arthritis is one of the most prevalent feeling incomidity and sever pain in the joint of the knee among individuals whom it is considered as the weakner illness, because of decisive being undistiguished its cause of beginning illness, severe pain, long trip, and its destructive role. The different treatments are considered to cease or retard this illness process but what it appea...

BACKGROUND Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a damage-associated molecular pattern (DAMP) which is released by activated phagocytes, and high levels are found in seronegative arthritides. In this study, we investigated the biomarker potential of systemic and local levels of these ...

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease associated with potentially debilitating joint inflammation, as well as altered skeletal bone metabolism and co-morbid conditions. Early diagnosis and aggressive treatment to control disease activity offers the highest likelihood of preserving function and preventing disability. Joint inflammation is characterized by synovitis, ...

experiments wee performed to evaluate the contralateral effect of adjuvant induced mono arthritis. in these experiments laser doppler imaging (ldi) was used to investigate changes in blood flow. adjuvant was applied to induce chronic inflammation. temperature and knee diameter increased in the first week after administration in the administrated knee joint.substance p (sp) (a neruokinin with a ...