Determination of the stoichiometry of macromolecular assemblies is fundamental to an understanding of how they function. Many different biophysical methodologies may be used to determine stoichiometry. In the past, both sedimentation equilibrium and sedimentation velocity analytical ultracentrifugation have been employed to determine component stoichiometries. Recently, a method of globally ana...

Serum C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were compared in 241 patients with rheumatoid arthritis (RA). There was a positive linear correlation between the 2 measurements with a high degree of variability. Neither age nor duration of RA had a detectable influence. The relationship between CRP and ESR was, however, altered by treatment with gold, penicillamine, ...

Electrophoretic studies and erythrocyte sedimentation rate measurements were carried out on normal and pathological human blood. An increase in alpha globulin levels appears to take place, as well as an increase in sedimentation rates, when there is present any considerable inflammation or tissue destruction, irrespective of its cause. A graphic correlation is presented between sedimentation ra...

The viscosity of the plasma was studied briefly by Fahraeus in his original investigations (1921) into the blood sedimentation rate. In 1940 further studies were made by T'Ang and Wang, who concluded that it gave a more accurate picture of the activity of disease processes than the erythrocyte sedimentation rate. The plasma viscosity technique was independently developed by Whittington and his ...

BACKGROUND Bleach-sedimentation may improve microscopy for diagnosing tuberculosis by sterilising sputum and concentrating Mycobacterium tuberculosis. We studied gravity bleach-sedimentation effects on safety, sensitivity, speed and reliability of smear-microscopy. METHODS This blinded, controlled study used sputum specimens (n = 72) from tuberculosis patients. Bleach concentrations and expos...

1. Using hemocyanin from Limulus polyphemus as a test material, the process of sedimentation in the angle centrifuge, operating both in vacuum and in the open air, has been investigated. 2. Sedimentation in a given field of force was found less efficient when centrifugation was conducted in the open air, because of thermal convection. 3. Correlations have been made with results obtained in the ...