Allergic diseases, including asthma, represent a major threat to human health. Over the three last decades, their incidence has risen in western countries. Aspirin treatment has been shown to improve allergic diseases, especially asthma, and the decreased use of aspirin has been hypothesized to contribute to the increase in childhood asthma. Because salicylate compounds suppress a number of enz...

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), ra...

Development of an advanced real-time multimedia application in DirectX environment based on the game project " Nyx " (Tworzenie zaawansowanej multimedialnej aplikacji czasu rzeczywistego w środowisku DirectX na przykładzie projektu gry komputerowej " Nyx ") Praca inżynierska Napisana pod kierunkiem Mgr inż. Krzysztofa Kalinowskiego Warszawa, grudzień 2006 Development of an advanced real-time mu...

   In this study, effect of asymmetric functionalized graphene oxide (Janus GO) on Young′s modulus and glass transition temperature of Polysulfone (PSf) ultrafiltration membranes was investigated. The membranes were prepared via phase inversion method and GO nanosheets were dispersed in casting solution by sonication. Results showed that the Normalized Young’s modulus (on the basis of neat ...

Janus kinase (JAK) inhibitors are efficacious for atopic dermatitis (AD). However, some patients receiving JAK develop acne, especially younger patients, or herpes zoster, elderly and desire to switch dupilumab. We experienced two with immediate exacerbation of AD after switching from upadacitinib dupilumab, herein report these cases. This phenomenon is attributed the difference in elimination ...

JAK2, a member of the Janus kinase (JAK) family of protein tyrosine kinases (PTKs), is an important intracellular mediator of cytokine signaling. Mutations of the JAK2 gene are associated with hematologic cancers, and aberrant JAK activity is also associated with a number of immune diseases, including rheumatoid arthritis. Accordingly, the development of JAK2-specific inhibitors has tremendous ...

The glucocorticoid dexamethasone is the standard of care in critically ill patients with COVID-19 to suppress inappropriately heightened inflammatory response (cytokine storm), but Janus kinase inhibitor baricitinib combined remdesivir has received emergency use authorization for same indication. As this writing, a hospitalized patient who evidence pneumonitis or hypoxia, we recommend using eit...

In this issue of Neuron, Berg et al. (2015) uncover multifaceted roles for janus kinase and microtubule-interacting protein 1 (JAKMIP1) in regulating neuronal mRNA translation and establish JAKMIP1 knockout mice as an important model to study autism spectrum disorder-associated phenotypes.

Cytokines have critical functions in regulating immune responses. A large number of these factors bind related receptors termed the Type I and Type II families of cytokine receptors. These receptors activate Janus kinases (Jaks) and Stat family of transcription factors. The essential and specific function of Jaks and Stats is particularly well illustrated by human and mouse mutations. The possi...