Introduction. Ivermectin is an antiparasitic drug that has been widely used in veterinary medicine. Parasitic diseases of farm animals cause great economic damage and pose the risk human infection. Prolonged dosage forms ivermectin are effective against them. The first step creation such a was preparation study polymeric microparticles polycaprolactone with encapsulated ivermectin. Aim. Obtaini...

Regular distribution of ivermectin reduces onchocerciasis transmission and morbidity by killing, within humans, the microfilarial stage of the parasite (microfilaricidal effect). In addition, ivermectin exerts a so-called embryostatic effect by which microfilarial production by the adult female worm becomes suppressed during a number of weeks after treatment. To assess the overall effect of ive...

This study was conducted to workout the prevalence of Gastrodiscus infection in horses in Lahore district and to check the efficacy of oxfendazole, albendazole and ivermectin against Gastrodiscus infection in horses. Five hundred faecal samples were collected and subjected to Coprological examination. From the Gastrodiscus positive horses 28 animals were selected for this study and were divided...

The glutamate-gated chloride channels (GluCls) are members of the ligand-gated ion channel superfamily that are thought to be involved in the mode of action of ivermectin and mechanism of resistance. Using reverse-transcriptase PCR techniques, 2 full-length GluCl cDNAs, encoding GluClalpha3 and GluClbeta subunits, were cloned from Cooperia oncophora, a nematode parasite of cattle. The two seque...

In a randomized open study, we compared the efficacy of a single dose of oral ivermectin (200 microg/kg) and oral albendazole (400 mg/day for 21 days) for the treatment of cutaneous gnathostomiasis. Thirty-one patients were randomly assigned to receive ivermectin (n = 17) or albendazole (n = 14). Thirteen of 17 patients who received ivermectin responded, 3 relapsed, and 1 was unresponsive (cure...

BACKGROUND Individuals with high intensity of Loa loa are at risk of developing serious adverse events (SAEs) post treatment with ivermectin. These SAEs have remained unclear and a programmatic impediment to the advancement of community directed treatment with ivermectin. The pathogenesis of these SAEs following ivermectin has never been investigated experimentally. The Loa/baboon (Papio anubis...

Anthelmintic resistance in parasitic nematodes of small ruminants is widespread and, in some parts of the world, threatens the sustainability of sheep production. The mechanisms whereby parasitic nematodes become resistant to anthelmintics, particularly ivermectin, remain to be determined. The majority of studies to date have investigated target site mutations; relatively little attention has b...

Avermectins are powerful endectocides with an established potential to reduce the incidence of vector-borne diseases. Here, we show that several avermectins inhibit the hepatic stage of Plasmodium infection in vitro Notably, ivermectin potently inhibits liver infection in vivo by impairing parasite development inside hepatocytes. This impairment has a clear impact on the ensuing blood stage par...

Although ivermectin is safe and well tolerated when distributed through mass treatment, pregnancy remains the major contraindication. PACQUÉ et al. (1990) considered that about half of the women in the first trimester of pregnancy might be treated inadvertently during community-based distribution of ivermectin, and stated that rates of miscarriage, stillbirth or major congenital malformation we...

Anthelmintic efficacy of levamisole, albendazole, ivermectin and morantel tartrate was evaluated in 75 sheep naturally parasitized with Haemonchus, Trichostrongylus, Oesophagostomum and Ostertagia spp. Results revealed that levamisole, albendazole, ivermectin and morantel tartrate were lOO, 98.82, 97.02 and 76.50 per cent effective, respectively in reducing the eggs per gram of faeces. The anim...