STUDY OBJECTIVE To compare operating conditions, intraoperative adverse events, recovery profiles, postoperative adverse effects, patient satisfaction, and costs of small-dose lidocaine spinal anesthesia with those of general anesthesia using fentanyl and propofol for elderly outpatient prostate biopsy. DESIGN Prospective, randomized, blind study. SETTING Outpatient anesthesia unit at a mun...

The aim of the present study is to observe the effects of multimodal analgesia (MMA) for postoperative pain on patients with lower limb fractures. One hundred patients (American Society of Anesthesiology I~II, ASAI~II) with lower limb fractures, undergoing open reduction and internal fixation, under combined spinal and epidural analgesia (CSEA) were randomly divided into four groups: Control gr...

PURPOSE Opioid-based intravenous patient-controlled analgesia (IV PCA) is popular method of postoperative pain control, but many patients suffer from IV PCA-related postoperative nausea and vomiting (PONV). In this retrospective observational study, we have determined independent predictors of IV PCA-related PONV and predictive values of the Apfel's simplified risk score in pursuance of identif...

Human neonates and infants can become tolerant and dependent during continuous fentanyl or morphine administration. The long-term consequences in these individuals as juveniles and adults are unknown. This study compared fentanyl self-administration behavior in juvenile rats that were opioid naive or were exposed chronically to fentanyl as infants. Postnatal day 14 infant rats remained naive or...

Background: The risk of anesthesia increases with age, so it is necessary to choose a safe and effective method. In this study, we compared the effectiveness of intranasal fentanyl with intravenous fentanyl in patients undergoing cataract surgery. Methods: This study was a triple-blind prospective randomized clinical trial (The patient, physician, and data analyzer were unaware of the patient ...

results the sedative effects were equal in the two groups (p > 0.05), but the analgesic effects were higher in the pf group than in the pk group (p < 0.05). the pk group had higher blood pressure levels in the eighth minute. respiratory rate, heart rate, and arterial oxygen saturation showed no significant differences between the groups (p > 0.05). endoscopist satisfaction, patient satisfaction...

background various attempts have been made to reduce the incidence of fentanyl-induced cough during anesthesia induction. we hypothesized that an appropriate dose of propofol might suppress fentanyl-induced cough. objectives a study had been designed to observe the effects of propofol on a fentanyl-induced cough during anesthesia induction. patients and methods we performed a randomized, double...

The United States and numerous other countries worldwide are currently experiencing a public health crisis due to the abuse of illicitly manufactured fentanyl (IMF) and its analogues. This manuscript describes the development of a liquid chromatography-tandem mass spectrometry-based method for the multiplex detection of N = 24 IMF analogues and metabolites in whole blood at concentrations as lo...

BACKGROUND Fentanyl, a synthetic opioid, is a popular choice amongst anaesthesiologists in the operating room. Pre induction intravenous fentanyl bolus is associated with coughing in 28-65% of patients. Fentanyl induced cough is not always benign and can be remarkably troublesome at the most critical moment of anaesthesia when airway reflex is lost. OBJECTIVES To study the effect of pre empti...

Previous studies have shown that uptake of the lipophilic opioid, fentanyl, by pulmonary endothelial cells occurs by both passive diffusion and carrier-mediated processes. To evaluate if the latter mechanism also exists in brain endothelium, transport of [3H]fentanyl was examined in primary cultured bovine brain microvessel endothelial cell (BBMEC) monolayers. Uptake of fentanyl appears to occu...