CONTEXT Recombinant human GH was approved by the United States Food and Drug Administration in 2003 for the treatment of idiopathic short stature (ISS). However, to date, the safety of GH in this patient population has not been rigorously studied. OBJECTIVE The objective of this study was to address the safety of GH treatment in children with ISS compared with GH safety in patient populations...

OBJECTIVE To assess the presence of insulin resistance (IR) in patients with type 1 diabetes (T1DM) according to the estimated glucose disposal rate formula (eGDR) and the insulin sensitivity score (ISS) and to estimate the correlation between these two measures and identify the clinical and laboratory markers related to IR. RESEARCH DESIGN AND METHODS Cross-sectional study of adults with T1D...

OBJECTIVE To examine how the setting in in situ simulation (ISS) and off-site simulation (OSS) in simulation-based medical education affects the perceptions and learning experience of healthcare professionals. DESIGN Qualitative study using focus groups and content analysis. PARTICIPANTS Twenty-five healthcare professionals (obstetricians, midwives, auxiliary nurses, anaesthesiologists, a n...

This paper introduces Index-Set Splitting (ISS), a technique that splits a loop containing several conditional statements into several loops with less complex control flow. Contrary to the classic loop unswitching technique, ISS splits loops when the conditional is loop variant. ISS uses an Index Sub-range Tree (IST) to identify the structure of the conditionals in the loop and to select which ...

Control Lyapunov functions (CLFs), CLF based controller designs and disturbance attenuation have attracted much attention in nonlinear control theory. However, little research exists that considers both the input constraint and the disturbance attenuation problems. For input constrained systems, we cannot stabilize under unbounded disturbances in general. Therefore, we propose an input-to-state...

The overall research goal of this project is to provide hypermedia functionality to information systems (ISs) not enhanced with hypermedia with minimal or no changes to the ISs. ISs dynamically generate their contents and thus require some mapping mechanism to automatically map the generated contents to hypermedia constructs (nodes, links and link markers) instead of hypermedia links being hard...

Although neurons attract the most attention in neurobiology, our current knowledge of neural circuit can only partially explain the neurological and psychiatric conditions of the brain. Thus, it is also important to consider the influence of brain interstitial system (ISS), which refers to the space among neural cells and capillaries. The ISS is the major compartment of the brain microenvironme...

This study develops an alternative methodology for the risk analysis of information systems security (ISS). an evidential reasoning approach under the Dempster-Shafer theory of belief functions. The approach has the following important dimensions. First, the evidential reasoning approach provides a rigorous, structured manner to incorporate relevant ISS risk factors, related countermeasures, an...

S The influence of the optical properties of inorganic suspended solids (ISS) on in-water algorithms was evaluated using an optical model in highly turbid coastal water, whose ISS concentration reached several hundred grams per cubic metre. The measurements were conducted in the upper Gulf of Thailand. The backscattering coefficient of the ISS was calculated using the Lorenz–Mie scattering theo...

Epileptiform activity is associated with impairment of brain function even in absence of seizures, as demonstrated by failures in various testing paradigm in presence of hypersynchronous interictal spikes (ISs). Clinical evidence suggests that cognitive deficits might be directly caused by the anomalous activity rather than by its underlying etiology. Indeed, we seek to understand whether ISs i...