Objective: To investigate the efficacy and safety of isosorbide mononitrate plus vinorelbine and cisplatin for treating patients with advanced stage non-small-cell lung cancer (NSCLC). Methods: 110 patients with stage IIIBIV NSCLC were randomly assigned to group A (57 cases) and group B (53 cases). Patients in group A were treated with vinorelbine (25 mg/m2) on days 1 and 8, and cisplatin (25 m...

AIMS Isosorbide-5-mononitrate (ISMN) is one of the most frequently used compounds in the treatment of coronary artery disease predominantly in the USA. However, ISMN was reported to induce endothelial dysfunction, which was corrected by vitamin C pointing to a crucial role of reactive oxygen species (ROS) in causing this phenomenon. We sought to elucidate the mechanism how ISMN causes endotheli...

The article studies the domestic market of vasodilators for cardiac diseases in Belarus by analyzing and comparing secondary marketing information. structure depending on manufacturing country was studied. It established that medicines containing isosorbide mononitrate/dinitrate have greatest number indications to use least side effects. dynamics changing sales group period 2010-2018 is present...

The title compound, [Ni(C(11)H(6)N(2)O)(H(2)O)(4)](NO(3))(2), was prepared by the reaction of Ni(NO(3))(2) and 4,5-diaza-fluoren-9-one (dafo). The crystal packing consists of a three-dimensional network via O-H⋯O hydrogen bonds between the coordin-ated water mol-ecules and the nitrate anions. The Ni atom lies on a special position (Wyckoff position 4e, site symmetry 2), as does the carbonyl O a...

BACKGROUND Isolated systolic hypertension is a highly prevalent disease among the elderly. The little available evidence on the efficacy of nitrates for treating the disease is based on small experimental studies. METHODS/DESIGN We performed a multicenter, randomized, double-blind, phase III, placebo-controlled trial in 154 patients aged over 65 years with refractory isolated systolic hyperte...

The antithrombogenic endothelial cell defense (ATECD) describes the properties that enable the endotheliiim to prevent circulating blood platelets from adhering to, or aggregating on, the vascular wall. ATECD was investigated in an experimental model in which bovine passage 0 cultured endothelial cells (EC) were incubated with aggregating platelets and autologous plasma in a computer-operated a...

Although nicorandil, N-(2-hydroxyethyl) nicotinamide dinitrate, is a nitrate ester, its cardiovascular action differs from that of nitrate compounds in several aspects. In this quantitative angiographic study, the acute coronary dilating effect of intracoronary nicorandil (0.25, 0.50, 1.0 mg) was compared with that of isosorbide dinitrate (ISDN; 1.0 mg) in 46 patients with or without ischemic h...

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