The possible functional coupling between beta1-adrenoceptor and MaxiK channels which results in smooth muscle relaxation was examined in the guinea-pig esophageal muscularis mucosae. Isoprenaline-elicited relaxation of esophageal smooth muscle was confirmed to be mediated through beta1-adrenoceptors as the response was competitively antagonized by a beta1-selective antagonist atenolol with a pA...

Myocardial infarction (MI) is one of the most common manifestations of cardiovascular disease. In recent years, accumulating evidence has indicated that the incidence and progression of cardiovascular disease may, to some extent, be modified by dietary means. In the present study, we investigated the protective effect of betaine, a potent lipotropic molecule, on changes in lipid profile and fat...

It has been demonstrated that Xenopus laevis oocytes are sensitive to catechol­ amines. The oocyte response is characterized as being of beta adrenergic nature and is electrophysiologically measured as a transient increase in potassium con­ ductance (hyperpolarizing current in holding potential —40 mV) (VanRenterghem et al.1985).The aim of this paper was to study the decline of the oocyte respo...

Experiences with a high degree of emotional salience are better remembered than events that have little emotional context and the amygdala is thought to play an important role in this enhancement of memory. Visual recognition memory relies on synaptic plasticity in the perirhinal cortex but little is known about the mechanisms that may underlie emotional enhancement of this form of memory. Ther...

Electrophysiological studies were performed in eight patients (four men and four women, mean (SD) age 24 (5) years with paroxysmal attacks of palpitation during or immediately after exercise. Five patients were competitive athletes at college. In two patients spontaneous supraventricular tachycardia during exercise was recorded by ambulatory electrocardiographic monitoring and in another it was...

In the present study, cardioprotective effect of aqueous extract of Garcinia indica Linn. fruit rinds in isoprenaline-induced myocardial infarction in Wistar albino rats was evaluated. In vitro total phenolic, total flavonoid content and 2, 2'-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. In vivo effect of aqueous extract of G. indica was evaluated in Wistar albino...

BACKGROUND AND PURPOSE Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity ...

Collett, A., S. J. Ramminger, R. E. Olver, and S. M. Wilson. -Adrenoceptor-mediated control of apical membrane conductive properties in fetal distal lung epithelia. Am J Physiol Lung Cell Mol Physiol 282: L621–L630, 2002. First published October 26, 2001; 10.1152/ajplung.00142.2001.— Distal lung epithelial cells isolated from fetal rats were cultured (48 h) on permeable supports so that transep...

ICI 118,551, 5 to 80 mg orally, did not significantly alter resting heart rate or blood pressure. In doses less than 40 mg the reduction in exercise tachycardia was under 10 beats/min. ICI 118,551, 10 to 40 mg, did not appear to reduce the maximum rise in systolic pressure with isoprenaline but did attenuate the changes in diastolic pressure, forearm blood flow and finger tremor. It also attenu...

Proline-rich protein (PRP) gene MP6 was isolated from a mouse BALB/c genomic DNA library in lambda EMBL3, characterised by hybridisation and restriction mapping and the promoter region, from -162 to +72 around the PRP consensus cap-site, was sequenced. In gel shift assays this region formed complexes C1 and C2 with parotid nuclear proteins which were induced by the beta-adrenergic agonist isopr...