Prediction of hot spots in protein interfaces provides crucial information for the research on protein-protein interaction and drug design. Existing machine learning methods generally judge whether a given residue is likely to be a hot spot by extracting features only from the target residue. However, hot spots usually form a small cluster of residues which are tightly packed together at the ce...

Diffusiophoretic motion of particles is influenced by the pH surrounding liquid, due to varying zeta potential surfaces at different pH. By using with an isoelectric point (pI), we study pH-dependent diffusiophoresis under a gradient. Various particle behaviors in absence and presence wall diffusioosmosis are demonstrated dead-end pore geometry.

THE latest work on the isoelectric point of lecithin is that of Price and Lewis [1933] investigating the macrocataphoresis oflecithin dispersions. As in previous work it was noted that the electrical properties of lecithin show a gradual change with the time. Thus the (presumably negative) mobility of a freshly prepared dispersion "increased, at given PHX with the age of the lecithin used, reac...

In this talk I summarize a recently proposed mechanism to understand ππ scattering to 1 GeV. The model is motivated by the 1/NC expansion to QCD, and includes a current algebra contact term and resonant pole exchanges. Chiral symmetry plays an important role in restricting the form of the interactions. The existence of a broad low energy scalar (σ) is indicated.

Novel strategies are developed for an efficient formal synthesis of (-)-mycalamide A. The left-hand side (-)-7-benzoylpederic acid is synthesized from (2S,3S)-2,3-epoxybutane. The key features include a highly regioselective Ru-catalyzed alkene-alkyne coupling reaction and a novel way to control the challenging C(7) stereocenter. The right-hand side was synthesized from (R)-pantolactone. The co...

The absorption and fluorescence properties of a barbiturate-type donor-pi-acceptor (D-pi-A) merocyanine dye are controlled by complexation with dimeric melamine receptors featuring different tether lengths.

The string equation of type (2, 2g + 1) may be thought of as a higher order analogue of the first Painlevé equation that corresponds to the case of g = 1. For g > 1, this equation is accompanied with a finite set of commuting isomonodromic deformations, and they altogether form a hierarchy called the PI hierarchy. This hierarchy gives an isomonodromic analogue of the well known Mumford system. ...

The acridizinium fluorophore was employed as water-soluble substitute for anthracene in PET probes and donor-pi-acceptor systems that may be used as fluorescent light-up probes and ratiometric probes in aqueous media.