bile duct ligation (bdl) is shown to induce cholestasis-related liver function impairments as well as consequent cognitive dysfunctions (i.e. impaired learning and memory formation). this study investigates the effects of cholestasis (14, 21 and 28 days post bile duct ligation) on spatial and non-spatial novelty detection, using a non-associative task. male mice weighing 30-35 g were used. chol...

Silent focal ischemic mini infarcts in the brain are thought to cause no clinically overt symptoms. Some populations of hippocampal cells are particularly sensitive to ischemic events, however, rendering hippocampal functions especially vulnerable to ischemia-induced deficits. The present study investigated whether an otherwise silent ischemic mini infarct in the hippocampus (HPC) can produce i...

objectives: the prospective and retrospective memory questionnaire (prmq) developed by smith (2000) and consists of a series of questions about memory weakness that can be encountered anyone in everyday life. the self-reported questionnaire has 16 items that assessing of prospective and retrospective memory problems in everyday life and the aim of the present research was to examine the investi...

Transient global amnesia is a disorder of mentation in which there is an abrupt onset of memory loss and disorientation without change in consciousness. The disorder involves events and activities of the present and recent past , but leaves personal identification intact. There is no associated focal or sensory deficit [1]. An episode usually lasts for several hours. Memory returns to normal wi...

BACKGROUND Reduction of blood pressure (BP) after stroke or TIA decreases stroke recurrence and is a major goal ofsecondary Stroke Prevention Clinics (SPCs). Health care providers need effective screening processes to identify those clients at highest risk of not achieving BP targets and those clients at highest risk ofnon-adherence to medication. METHODS This multicentred, randomized control...

Functional imaging studies consistently find that older adults recruit bilateral brain regions in cognitive tasks that are strongly lateralized in younger adults, a characterization known as the Hemispheric Asymmetry Reduction in Older Adults model. While functional imaging displays what brain areas are active during tasks, it cannot demonstrate what brain regions are necessary for task perform...

Transient global amnesia (TGA) is characterized by anterograde memory disturbance of sudden onset that lasts for 1 to 24 hours. Orientation in space and time is impaired while consciousness remains undisturbed. T r a n s i e n t d i f f u s i o n w e i g h t e d imaging abnormalities involving the hippocampus as wel l as s tressful s i tuations precipitat ing Transient Global Amnesia have been ...

OBJECTIVES Risk modification through behavior change is critical for primary and secondary stroke prevention. Theories of health behavior identify perceived risk as an important component to facilitate behavior change; however, little is known about perceived risk of vascular events among stroke survivors. METHODS The SWIFT (Stroke Warning Information and Faster Treatment) study includes a pr...

background: stroke is the most common neurologic disease and an important cause of morbidity and mortality. headache is an initial presenting feature of ischemic stroke and sometimes preceedes the development of stroke and thus, provides an opportunity for offering preventive measures. the aim of the present study was to determine the association of new onset headache with stroke. methods: a to...

Perception of the passage of time is essential for safe planning and navigation of everyday activities. Findings from the literature have demonstrated a gross underestimation of time interval in right-hemisphere damaged neglect patients, but not in non-neglect unilaterally-damaged patients, compared to controls. This study aimed to investigate retrospective estimation of the duration of a targe...