Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties. We studied the effect of soluble thrombomodulin (sTM) in a hypoperfusion model of ischemic kidney injury. To markedly reduce infrarenal aortic blood flow and femoral arterial press...

Therapeutic approaches to block the progression from acute kidney injury to chronic kidney disease are currently lacking. Endothelin-1 (ET-1) is a powerful vasoconstrictor, induced by hypoxia, and previously implicated in renal ischemia-reperfusion (IR) injury. This study tested the hypothesis that blunting the vascular influence of ET-1, either through endothelin ETA receptor blockade (ABT-627...

background: renal ischemia reperfusion injury may occur in a variety of clinical situations, following a transient drop in total or regional blood flow to the kidney. this study was performed to investigate the protective effects of different antioxidants such as vitamin c, vitamin e, hydrocortisone and combination of these agents against experimental renal ischemia-reperfusion injury. method:...

s and Posters M Kaßmann, Y Zhu, Zh M Zhu, M Tepel, M Gollasch. Posterpresentation: TRPV1 and acutekidney injury. Symposium of the mechanism of AKI, 2012, Copenhagen, Damark. Y Zhu, M Fechner, U Hoff, G Bubalo, T Hoppenheit, C Westphal, M Blum, W Schneider, MRothe, WH Schunck, D Dragun. Posterpresentation: 20-Hydoxyeicosatetraenoic acid (20-HETE)overproduction exerts ischemic acute k...

BACKGROUND Ischemia-reperfusion (IR) injury is one of the most common causes of renal dysfunction. There is increasing evidence about the role of the reactive oxygen species (ROS) in these injuries and endogenous antioxidants seem to have an important role in decreasing the renal tissue injury. OBJECTIVES The aim of this study was to compare the effect of recombinant human erythropoietin (EPO...

A cute renal failure after transplantation remains a major cause of morbidity. Moreover, Initial graft dysfunction may have adverse effects on ultimate graft function, especially when cyclosporine Is used in the immunosuppression regimen (1 ,2). We have observed, as have others, that atrial natriuretic peptide (ANP) may ameliorate warm ischemic injury to the kidney (3,4). There is, however, lit...

Mesenchymal stem cell (MSC) administration is known to enhance the recovery of the kidney following injury. Here we tested the potential of hypoxic-preconditioned-MSC transplantation to enhance the efficacy of cell therapy on acute kidney injury (AKI) by improving MSC migration to the injured kidney. Cobalt was used as hypoxia mimetic preconditioning (HMP). MSC were subjected to HMP through 24 ...