نتایج جستجو برای: isatin n sulfonic issa
تعداد نتایج: 980367 فیلتر نتایج به سال:
a number of n-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against adp and arachidonic acid induced platelet aggregation in human plasma was determined. the desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. the so formed compound was then act...
The free boundary of smectic A (SmA), nematic and isotropic liquid phases were studied using a polarized optical microscope, an interferometric surface structure analyzer (ISSA), an atomic force microscope (AFM) and a scanning near-field optical microscope (SNOM). Images of the SmA phase free surface obtained by the polarized microscope and ISSA are in good correlation and show a well-known foc...
Stereoselective Organocatalytic Synthesis of Oxindoles with Adjacent Tetrasubstituted Stereocenters.
Oxindoles with adjacent tetrasubstituted stereocenters were obtained in high yields and stereoselectivities by organocatalyzed conjugate addition reactions of monothiomalonates (MTMs) to isatin-derived N-Cbz ketimines. The method requires only a low catalyst loading (2 mol %) and proceeds under mild reaction conditions. Both enantiomers are accessible in good yields and excellent stereoselectiv...
We describe an efficient one-step synthesis of pyrrolo[3,4-c]quinolinedione derivatives using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and β-ketoamides. It is the first direct conversion of isatins to pyrrolo[3,4-c]quinolinedione derivatives via C-N bond cleavage and isatin ring expansion. Furthermore, this reaction provides a one-step synthetic route for the prod...
The title spiro-oxindole compound, C(26)H(23)N(3)O(3), was prepared by the reaction of isatin, 3-methyl-1-phenyl-2-pyrazolin-5-one and 5,5-dimethyl-cyclo-hexane-1,3-dione in an ethanol solution. The fused cyclo-hexene ring adopts an envelope conformation. The dihedral angle between the aromatic and pyrazoline rings is 23.70 (8)°. An intra-molecular C-H⋯O inter-action occurs. The crystal structu...
Paradigma integratif interkonektif yang diusung oleh Amin Abdullah adalah usaha untuk menjadikan sebuah keterhubungan antara keilmuan agama dan umum. Muara dari paradigm ini mengalami proses obyektivikasi dimana tersebut dirasakan orang non Islam sebagai sesuatu natural (sewajarnya), tidak perbuatan keagamaan. saling melumatkan peleburan umum agama. Tujuan penelitian mengetahui bagaimana penera...
In the title compound, C(15)H(10)FN(5)O(3)S, an intra-molecular N-H⋯N hydrogen bond generates an S(5) ring, whereas N-H⋯O and C-H⋯S inter-actions complete S(6) ring motifs. The dihedral angle between the isatin ring system and the fluoro-benzene ring is 5.96 (6)° and the complete mol-ecule is close to planar (r.m.s. deviation for all the non-H atoms = 0.112 Å). In the crystal, mol-ecules are li...
The title compound, C(8)H(7)ClN(2)O(2), is an inter-mediate in the synthesis of 5-chloro-isatin, which can be further transformed to 5-chloro-2-indolinone via a Wolff-Kishne reduction. The C(2)N acetamide plane forms a dihedral angle of 6.3 (3)° with the benzene ring. An intra-molecular C-H⋯O inter-action results in the formation of a six-membered ring. In the crystal, inter-molecular N-H⋯O, N-...
A fatal case of vaccinia necrosum treated with antivaccinial gamma globulin and N-methyl isatin beta-thiosemicarbazone (33T57) is described. Histological abnormalities found at necropsy included intranuclear as well as cytoplasmic inclusion bodies, absence of lymphoid germinal centres, grey hepatization, and bronchiolar epithelial hyperplasia. Virus titres were highest in the original skin lesi...
Isatin (1H-indole-2,3-dione) and its analog, are versatile substrates which acts as a precursor for large number of pharmacologically active compounds, thus having a significant importance in the synthesis of different heterocyclic compound.Isatin shows varity of biological activities such as antimicrobial, anticancer, antiviral, anticonvulsant, antiinflammatory and analgesic.This review focuse...
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