The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that show potential in overcoming MDR are the N-alkylated isatins. In particular 5,7-dibromo-N-alkylisatins are potent microtubule destabilizing agents that act to depolymerize microtubules, induce apoptosis and inhibit primary tumor growth i...

The minimal inhibitory concentrations of various antibiotics for a strain of Streptococcus pyogenes and a stable L-form of it were determined. These results were evaluated with those of other investigators similarly performed with S. faecalis and derived protoplasts. Differences in reaction to puromycin, bacitracin and ristocetin were apparent only between the wall-less derivatives. The polyene...

Imaging of programmed cell death (apoptosis) is important in the assessment of therapeutic response in oncology and for diagnosis in cardiac and neurodegenerative disorders. The executioner caspases 3 and 7 ultimately effect cellular death, thus providing selective molecular targets for in vivo quantification of apoptosis. To realize this potential, we aimed to develop 18F-labeled isatin sulfon...

Understanding the precise molecular arrangement of chiral supramolecular polymers is essential not only to comprehend complex superstructures like proteins and DNA but also for development next-generation optoelectronic materials, including materials displaying high-performance circularly polarized luminescence (CPL). Herein, we report first polymer systems based on hydrazone–pyridinium conjuga...

The title compound, C(13)H(15)NO(3), was synthesized by the Aldol reaction of isatin and 3-methyl-butan-2-one refluxing in methanol catalyzed by dimethyl-amine. The packing of the mol-ecules in the crystal structure features inter-molecular N-H⋯O and O-H⋯O hydrogen bonds.

BACKGROUND/AIM Atrial natriureticpeptide (ANP) is known as a protective agent against ischemia-reperfusion injuryfor cardiomyocytes. We compared the hemodynamic effects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed by reperfusion in exercised rat hearts with nonexercised ones. MATERIALS AND METHODS Isolated hearts were perfused in 4 exercised (E) groups af...

oxidation reaction of indole to isatin was performed in the presence of fe3o4 nanoparticles (as catalyst) and commercial grade perhydrol (as oxidant). magnetite nanoparticles were synthesized via chemical precipitation method and characterized by xrd and tem techniques. the efficiency of reaction was obtained from gc analysis of the mixture. the catalyst was easily separated from the reaction m...

In the title compound, C(18)H(11)ClN(2)O(2), the isatin and 2-chloro-3-methyl-quinoline units are both almost planar, with r.m.s. deviations of 0.0075 and 0.0086 Å, respectively, and the dihedral angle between the mean planes of the two units is 83.13 (7)°. In the crystal, a weak inter-molecular C-H⋯ O inter-action links the mol-ecules into chains along the c axis.