In this work, polymer composite materials based on linear low-density polyethylene and iron oxide nanoparticles were obtained. Nanoparticles of synthesized in plasma discharge under ultrasonic cavitation. When preparing materials, the concentration was varied from 0.5 to 20 wt. %. Measurements elastic modulus as well dynamic tests revealed strong dependence mechanic properties nanoparticle conc...

Nanoparticle-functionalized 2D material networks are promising for a wide range of applications, but in situ formation nanoparticles is commonly challenged by rapid growth. Here, we demonstrate controlled synthesis small and dispersed iron oxide on reduced graphene (rGO) through localized heating with microwaves low-cost nitrate as the precursor. The strong coupling microwave radiation rGO netw...

Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal form of cancer. In 2012, the incidence of PDAC was 43,920. Five-year survival for patients with PDAC is around 6%, regardless of staging, making PDAC one of the deadliest forms of cancer. One reason for this dismal prognosis is chemoresistance to the current first-line therapy, gemcitabine. There are multiple factors that contribu...

Magnetic hyperthermia, or the heating of tissues using magnetic materials, is a promising approach for treating cancer. We found that human mesenchymal stem cells (MSCs) isolated from various tissues and MSCs expressing the yeast cytosine deaminase∷uracil phosphoribosyl transferase suicide fusion gene (yCD∷UPRT) can be labeled with Venofer, an iron oxide carbohydrate nanoparticle. Venofer label...

The adoption of magnetic hyperthermia as either a stand-alone or adjunct therapy for cancer is still far from being optimised due to the variable performance found in many iron oxide nanoparticle systems, including commercially available formulations. Herein, we present a reproducible and potentially scalable microwave-based method to make stable citric acid coated multi-core iron oxide nanopar...

There has been great interest in the use of nanoparticles for imaging, particularly in multimodal applications (e.g., combination of MRI and fluorescence). Yet creating particles with multiple functionalities has been challenging. Here, we report the synthesis of pH sensitive, fluorescent-magnetic, nanocomposites created through a simple aqueous procedure. Separately synthesized superparamagnet...

AIM To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors. MATERIALS & METHODS Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged ...

Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cy...

Currently available cancer therapies can cause damage to healthy tissue. We developed a unique method for specific mechanical lysis of cancer cells using superparamagnetic iron oxide nanoparticle rotation under a weak alternating magnetic field. Iron oxide core nanoparticles were coated with cetuximab, an anti-epidermal growth factor receptor antibody, for specific tumor targeting. Nude mice be...

Coprecipitated ferrite nanoparticles were coated with carbon using a hydrothermal method. From transmission electron microscope pictures, we could see that the coated iron oxide nanoparticles were spherical in shape with an average diameter of 90 nm. The strong bonding of carbon on the nanoparticle surfaces was checked by noting the C = O and C = C vibrations in Fourier transform infrared spect...