background: several studies have suggested that obesity-related inflammation can lead to altered iron metabolism as well as higher rates of iron deficiency in obese than in normal-weight subjects. given that at a population level, premenopausal women are at higher risk of iron deficiency, the purpose of this study was to investigate iron and inflammatory status in young overweight and obese wom...

conclusions further studies on the role of hepcidin in pathogenesis of chc are needed to assess the potency of its use in antiviral treatment. results patients with chc had lower hepcidin mrna expression and more frequently iron deposits in hepatocytes than subjects with chb did. in chc group, hepcidin mrna expression was positively correlated with alanine aminotransferase activity and serum ir...

IT \\TAS DEMONSTRATED in previous p” that a major factor in tIle C tt1SttiO11 of the anemia associated with marked hookworm infection is the considerable intestinal l)locd less proclilcedI l)y the infection. It was also showii that, although d significant amount of iron contained in the lost blood is reai)Sori)e(l from the intestinal tract,1 sufficient iron may I)e lost to upset the 1)alaIlce a...

Increased serum ferritin associated with mild hepatic iron accumulation, despite preserved upregulation of the iron hormone hepcidin, is frequently observed in patients with dysmetabolic overload syndrome (DIOS). Genetic factors and Western diet represent predisposing conditions, but the mechanisms favoring iron accumulation in DIOS are still unclear. Aims of this study were to assess the effec...

indium is a heavy metal belonging to group iiia. it is believed that indium may interfere with iron metabolism from the sites of absorption, transportation, utilization and storage in the cells. the present investigation was established to study and compare the binding of iron and indium to human apo-transferrin (apo-tf). pure human apo-tf was used and the binding activity of iron and indium, a...

Background: It is clear that Helicobacter pylori (H. pylori) is a spiral bacterium that infects human and causes gastritis and peptic ulcer. The aim of this study was to determine the relationship between H .pylori infection and the iron status of the body. Methods: This study was conducted in Shahid Beheshti Hospital of Babol University of Medical Sciences, Babol, Iran from August 2007 to July...

Background Endemic goiter is present in most parts of Iran. Iron deficiency adversely affects the physiology of thyroid. The initial steps of thyroid hormone synthesis are catalyzed by thyroperoxidases and are dependent on iron. In many developing countries, children are at high risk of both goiter and iron deficiency anemia. In addition, iron deficiency may alter central nervous system contro...

In biology, redox reactions are essential and sometimes harmful, and therefore, iron metabolism is tightly regulated by cuproproteins. Since the state of copper in iron overload syndromes remains unclear, we investigated whether copper metabolism is altered in these syndromes. Eleven patients with iron overload syndromes participated in this study. The clinical diagnoses were aceruloplasminemia...

Iron is essential in oxygen transport and participates in many enzymatic systems in the body, with important roles in collagen synthesis and vitamin D metabolism. The relationship between iron and bone health comes from clinical observations in iron overload patients who suffered bone loss. The opposite scenario--whether iron deficiency, with or without anemia, affects bone metabolism--has not ...

As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in biology and medicine. At the cellular level, the basic molecular framework for the regulation of iron uptake, storage, and utilization has been defined. Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the...