Introduction: Age-related cognitive decline decreases with aerobic physical exercise in many animal models and humans. Irisin, a myokine its’ precursor FNDC5, has increased hippocampal development to improve learning memory. This study aims determine the association between irisin, activity enhancement of spatial adult mice. Methods: Three experimental studies will be conducted explore role FND...

Obesity and obesity-related diseases including insulin resistance metabolic syndrome (MetS) pose a great risk for cardiovascular development. Skeletal muscle as an endocrine organ has pivotal role on secreting physiological factors such hormones myokines. Irisin that is one of these miyokines also known hormone secreted mainly from tissue in response to exercise. It dependent fibronectin type I...

BACKGROUND Omega-3 fatty acids have a protective role against cardiovascular disease and these protective properties are attributed to its anti-inflammatory effects. Myokines have anti-inflammatory properties and thereby reduce low-grade inflammation. Irisin, as a myokine, is considered to be therapeutic for human metabolic diseases. This study was conducted to determine the effects of Omega-3 ...

BACKGROUND Betatrophin may increase islet β cell proliferation in insulin resistance and irisin may improve glucose tolerance in mice. To examine the relationship between betatrophin and irisin, we investigated it in middle-aged Chinese subjects with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM). METHODS A total of 460 permanent residents of Fengxian District, aged 40-60 ...

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in industrialized countries. The increasing prevalence of NAFLD mirrors the outbreak of obesity in western countries, highlighting the connection between these two conditions. Nevertheless, there is currently no specific pharmacotherapy for its treatment. Accepted management begins with weight loss and ex...

Background & Aims: Transforming white adipose tissue to brown adipose tissue is considered a solution to overcome undesirable effects of obesity in human beings. Thus, the aim of this research was to investigate the effect of eight weeks of high intensity interval training (HIIT) on serum amounts of fibroblast growth factor 21 (FGF21) and Irisin in sedentary obese women. Materials & Methods: T...

OBJECTIVE The irisin, recently identified novel molecule, has been shown to be secreted from fibronectin type III domain containing 5 (FNDC5) of skeletal muscle by an unknown protease. It has been proposed that this molecule plays an important role in converting the white adipose tissue to brown adipose tissue and regulating the energy expenditure. Apart from this, its expression and role in va...

AIMS/HYPOTHESIS Recently, the novel myokine irisin was described to drive adipose tissue 'browning', to increase energy expenditure, and to improve obesity and insulin resistance in high fat-fed mice. Here, we assessed whether common single nucleotide polymorphisms (SNPs) in the FNDC5 locus, encoding the irisin precursor, contribute to human prediabetic phenotypes (overweight, glucose intoleran...

Background We examined the effect of antioxidant supplementation and exercise on irisin within postmenopausal women. Methods Forty-eight participants (age: 55.7 ± 4.9 years; weight: 68.0 ± 6.3 kg; BMI 27.0 ± 2.7; mean ± SD) were randomized into four groups for the eight week intervention: control group (CG; n = 12), resistance training group (RTG; n = 12), supplementation with Zataria multifl...