The mitochondrial DNA (mtDNA) mutations in mitochondrial coding and non coding regions seem to be important in carcinogenesis. The aim of this investigation was to evaluate coding region (mt-tRNA(Phe) and tRNA(Pro)) and non-coding sequence, mitochondrial displacement loop (mtDNA D-loop), in the cancerous and non-cancerous lesions of Iranian patients with breast cancer (BC). Genomic DNA was extr...

BACKGROUND Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte antigen (HLA) class-II alleles or haplotypes. OBJECTIVES The present study was undertaken to determine the frequency of HLA class-II alleles in Ir...

BACKGROUND There are insufficient data available on utilization and health care costs of non-alcoholic fatty liver disease. The cost data for different health conditions and services is a major gap in Iranian health system. So this study is the primary or first step towards filling this gap. OBJECTIVES This study aims to estimate the diagnosis and treatment costs of Non-alcoholic Fatty Liver....

Sakineh HajEbrahimi, Ali Janati, Edris Hasanpoor, Morteza Arab-Zozani, Mobin Sokhanvar, Fariba Pashzadeh, Elaheh HaghGoshyie. Professor of urology, Iranian EBM Centre of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran; Associate professor of Healthcare Management, Iranian Center of Excellence in Health Management (IceHM), Tabriz University of Medical Sciences, Tabriz, Iran; Ph.D...

OBJECTIVE Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of thi...

Autosomal recessive non-syndromic hearing loss (ARNSHL) is defined as a genetically heterogeneous disorder. The aim of the present study was to screen for pathogenic variants in an Iranian pedigree with ARNSHL. Next-generation targeted sequencing of 127 deafness genes in the proband detected two novel variants, a homozygous missense variant in PTPRQ (c.2599 T>C, p.Ser867Pro and a heterozygous m...

versity, Frankfurt am Main. Originally more than 100 abstracts were submitted to the conference, from which 36 were selected for oral presentations and 19 for poster presentations. A number of contributors to the conference subsequently submitted their papers for publication in this issue of Orientalia Suecana, and after the reviewing process, the seven papers below were finally selected for pu...

The physician's acquittal has obsessed Iranian legislator's mind to a large extent. This is exclusively observed in Iranian statuses and specifically in Shi'ite school of though. Muslim jurists' opinions play a very important role in enacting legal articles related to it. After reviewing the literature, the authors tried to pick and collect common features of physician's responsibilities and du...

Paralytic ileus is type of functional obstruction caused by the lack of intestinal peristalsis without any mechanical obstruction. This interference of the flow of intestinal contents often leads to intestinal obstruction. Paralytic ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced (1). The incidence of paralytic ileus is high especially after abd...

BACKGROUND Once considered as the main public health problem in developed countries, obesity has become a major problem throughout the world and developing countries, like Iran, are joining the global obesity pandemic. We determined the prevalence of overweight, obesity, and hypertension in a large cohort of Iranians and compared age-adjusted rates with the rates in the US. METHODS Golestan C...