the present work investigated the preparation of biodegradable beads with alginate polymer by ionotropic gelation method to improve the control release properties of the antibiotic rifampicin. ionotropic gelation method was applied to prepare beads using calcium chloride (cacl2) as cationic component and alginate as an anionic component. in this method, adding 0.5% w/v polyvinyl alcohol (pva) t...

Here we present a theory of ion aggregation and gelation room temperature ionic liquids (RTILs). Based on it, investigate the effect correlated transport—ionic conductivity transference numbers—obtaining closed-form expressions for these quantities. The depends maximum number associations cation anion can form strength their association. To validate presented theory, perform molecular dynamics ...

We present an approximation scheme to the master kinetic equations for aggregation and gelation with thermal breakup in colloidal systems with variable attraction energy. With the cluster fractal dimension df as the only phenomenological parameter, rich physical behavior is predicted. The viscosity, the gelation time, and the cluster size are predicted in closed form analytically as a function ...

The main aim of the present investigation was to develop in situ gelling mucoadhesive liquid suppositories of ondansetron by using mucoadhesive polymers such as sodium alginate, methyl cellulose and polyvinylpyrrolidone. Polyethylene glycol was used to modify gelation temperature. Mucoadhesive liquid suppositories of ondansetron were prepared by adding mucoadhesive polymers (0.8% w/w) to the fo...

The reaction process and corresponding mechanism of coagulation and gelation of native soy protein isolates (SPIs) induced by microbial transglutaminase (MTGase) were investigated. The protein constituents of SPIs, including a majority of subunits of b-conglycinin and acidic subunits of glycinin, could be polymerized by MTGase to form high weight molecular (WM) biopolymers. Both the coagulation...

The aim of this study was the formulation and examination of a novel thermoresponsive and bioadhesive, in situ gelling drug delivery system, which can be used in the treatment of oesophageal pain and inflammation. A bioadhesive cellulose derivative (Metolose) 60SH) was used as a thermoresponsive material, because Metolose has thermal gelation properties at certain temperature. The thermal gelat...

A new series of lipophilic cholesteryl derivatives of 2,4,6-trichloro-pyrimidine-5-carbaldehyde has been synthesized. Oxyethylene spacers of variable lengths were inserted between the hydrogen bonding promoting pyrimidine core and the cholesteryl tail in order to understand their effect on the self-assembly of these compounds. Only compound 1a with the shortest spacer formed a gel in organic so...

The Dictyostelium discoideum gelation factor is a two-chain actin-cross-linking protein that, in addition to an N-terminal actin-binding domain, has a rod domain constructed from six tandem repeats of a 100-residue motif that has an immunoglobulin fold. To define the architecture of the rod domain of gelation factor, we have expressed in E. coli a series of constructs corresponding to different...

Understanding the gelation of liquids by low molecular weight solutes at low concentrations gives an insight into many molecular recognition phenomena and also offers a simple route to modifying the physical properties of the liquid. Bis-(α,β-dihydroxy ester)s are shown here to gel thermoreversibly a wide range of solvents, raising interesting questions as to the mechanism of gelation. At gelat...