The use of thyroid-depressant agents in the control of hyperthyroidism has raised questions concerning their relationship to other goitrogens and their mode of action. Other problems have been encountered as well, particularly with respect to toxic reactions, the effect of preliminary iodine administraton, and the control of the hypothyroid state which may result. The information available on t...

The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2 -yl)methyl]aniline (IVa-IVj). Structures of the compounds synthesized were confirmed by IR, (1)HNMR and MA...

Speculation as to the functions of the thyroid glands has taken two main directions: some suppose that these organs elaborate an internal secretion which is of itself necessary for certain processes of metabolism, while others think that their chief function is to neutralize poisonous substances originating in the body (“enterotoxines”) or introduced into it from without (iodine, for example). ...