Carfilzomib (CFZ) is a second generation proteasome inhibitor approved for the treatment of patients with multiple myeloma. It induces apoptosis in human cancer cells; but the underlying mechanisms remain undefined. In the present study, we show that CFZ decreases the survival of several human cancer cell lines and induces apoptosis. Induction of apoptosis by CFZ occurs, at least in part, due t...

Motivated by the work of Zargar and Zamani, we introduce a family elliptic curves containing several one- (respectively two-) parameter subfamilies high rank over function field $\mathbb{Q}(t)$ $\mathbb{Q}(t,k)$). Following approach Moody, construct two infinitely many at least 5 $\mathbb{Q}(t,k)$. Secondly, deduce other this family, induced edges rational cuboid five independent $\mathbb{Q}(t)...

INTRODUCTION Large, functional, disaster exercises are expensive to plan and execute, and often are difficult to evaluate objectively. Command and control in disaster medicine organizations can benefit from objective results from disaster exercises to identify areas that must be improved. OBJECTIVE The objective of this pilot study was to examine if it is possible to use performance indicator...

a typical scenario involving Soar-based RWA IPs. 1. Abstract There are two RWA in the scenario, just behind the The Soar/IFOR project has been developing ridge, indicated by the contour lines. The other intelligent pilot agents (henceforth IPs) for vehicles in the figure are a convoy of "enemy" participation in simulated battlefield environments. ground vehicles  tanks and anti-aircraft vehicl...

Recent drought events underscore the vulnerability of Amazon forests to understorey fires. The long-term impact of fires on biodiversity and forest carbon stocks depends on the frequency of fire damages and deforestation rates of burned forests. Here, we characterized the spatial and temporal dynamics of understorey fires (1999-2010) and deforestation (2001-2010) in southern Amazonia using new ...

Spotting ignition by lofted firebrands is a significant mechanism of fire spread, as observed in many largescale fires. The role of firebrands in fire propagation and the important parameters involved in spot fire development are studied. Historical large-scale fires, including wind-driven urban and wildland conflagrations and post-earthquake fires are given as examples. In addition, research o...

The paper investigates the ability to learn from an aircraft accident as the opportunities for learning diminish with the decline in the accident rate. A safety compromising case is studied as the processes of aircraft accident intervention and recovery can degrade the ability of an aircraft accident investigation process to enhance aviation safety by revealing accident causation. In the case s...