This part of the review focuses on proposed involvement gut microbiota in realization genetic risk multiple sclerosis, formation intestinal microbiome early life, and provides data supporting hypothesis that aberrant life may be a predisposing factor to sclerosis.

The development process involved developers contribution based his/her cognitive thinking in the real time process. The developer’s performance is dynamic as per their cognitive load. The cognitive load is un-deterministic as well hidden and integrated in the developer’s process. This paper attempt to identify software developer cognitive measure which influences the development process using n...

In this study, we test the predictions of the high initial damage load (HIDL) hypothesis, a scientific idea that early development of living organisms produces an exceptionally high load of initial damage, which is comparable with the amount of subsequent aging-related deterioration accumulating during the rest of the entire adult life. This hypothesis predicts that even small progress in optim...

The present work proposes, validates and verifies a very short and short time bus active load forecast model that takes into account the regional differences and the dynamics of the load demand in a heterogeneous electric energy market such as the market of the State of Santa Catarina. This work also compares the performance of this model with the Oliveira (1999) model that has proposed for rea...

Runners do not have a greater prevalence of knee osteoarthritis (OA) than nonrunners. The hypothesis that joint loads in running do not cause OA is forwarded. Two mechanisms are proposed: 1) cumulative load, which is surprisingly low in running, is more important for OA risk than peak load, and 2) running conditions cartilage to withstand the mechanical stresses of running.

Studies on visual cognitive load have reported inconsistent effects of distractor interference when distractors have visual characteristic that are similar to the cognitive load. Some studies have shown that the cognitive load enhances distractor interference, while others reported an attenuating effect. We attribute these inconsistencies to the amount of cognitive load that a person is require...

The effects of perceptual load and those of target-stimulus degradation on distractor processing were contrasted. Targets either had to be found among several nontargets (high perceptual load) or were presented alone and were intact (low perceptual load), had reduced size and contrast (Experiment 1), had reduced duration and were followed by a mask (Experiment 2), or had reduced visual acuity o...

Inhibitors of sodium-glucose cotransporter 2 (SGLT2) are a novel class of antidiabetes drugs, and members of this class are under various stages of clinical development for the management of type 2 diabetes mellitus (T2DM). It is widely accepted that SGLT2 is responsible for >80% of the reabsorption of the renal filtered glucose load. However, maximal doses of SGLT2 inhibitors fail to inhibit >...