Many ionic liquids and low molecular weight polar solvents have been reported to support amphiphile self-assembly, with most of these reported for the first time in the last decade. This phenomenon is attributed to the solvophobic effect (analogous to the hydrophobic effect in water). However, to date there has been no systematic study which evaluates micelle formation in a large library of non...

Hyaluronan is a biopolymer suitable as a targeting unit in drug delivery systems according to affinity of hyaluronan to CD-44 receptor of cancer cells. We suppose that hyaluronan, when interacts with cationic surfactant, influences hydration of Stern layer of CTAB which affects fluorescence properties of 1-naphthol. We study excited state proton transfer of 1-naphthol in aqueous solution and in...

Amphotericin B (AmB) and Nystatin (Nys) are the drugs of choice for treatment of systemic and superficial mycotic infections, respectively, with their full clinical potential unrealized due to the lack of high therapeutic index formulations for their solubilized delivery. In the present study, using a coarse-grained (CG) molecular dynamics (MD) simulation approach, we investigated the interacti...

A filament stretching extensional rheometer and capillary breakup extensional rheometer are used to measure the extensional rheology of a series of wormlike micelle solutions experiencing a uniaxial elongational flow. The experiments are performed using a series of wormlike micelle solutions of both cetylpyridinium chloride and sodium salicylate NaSal in an aqueous sodium chloride solution and ...

Micelle with mesomeric polyleucine (PDLLeu) core demonstrated the most uniform morphology, the smallest diameter and the highest drug loading capability compared to those with dextrorotatory (PDLeu), levorotatory (PLLeu) and racemic PLeu (PD/LLeu) cores. In addition, the modification with c(RGDfC) endowed the optimal PDLLeu micelle with enhanced intracellular drug release and cytotoxicity, indi...

Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.

As an alternative to cell specific cancer targeting strategies (which are often afflicted with the heterogeneity of cancer cells as with most biological systems), a novel polymeric micelle constitute of two block copolymers of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine)-TAT (transactivator of transcription) and poly(L-histidine)-b-poly(ethylene glycol) was developed. The mic...

acanthophyllum laxiusculum is one of the most widely distributed species of the genus in iran that flourishes in steppe and mountainous regions of the country. in the present study, water-soluble content of a. laxiusculum roots was extracted by boiling water and further successively purified partially by a defined solvent system. surface tension measurements revealed the ability of plant extrac...

Supramolecular carriers such as micelles can be used to noncovalently bind drug molecules for pharmaceutical applications. However, these carriers can fundamentally affect diffusion-based drug transport due to host-guest coupled diffusion. We report a ternary interdiffusion study on an ionic drug in aqueous micellar solutions. Specifically, high-precision Rayleigh interferometry was used to det...

Novel nanosized lead tungstate (PbWO4) hollow spindles were successfully synthesized, for the first time, via a Pluronic P123- (EO20PO70EO20-) assisted sonochemical process. The triblock copolymer acted as a structure-directing agent and played a key role in the formation of the hollow spindles. An in situ micelle templating mechanism has been proposed for the possible formation mechanism of th...