Pentanema divaricatum species was collected from Arıcak (Elazığ) district in Turkey and it given a new record for the Flora of Turkey. The description, details photographs distribution maps this are also given.

Enterocutaneous fistulas cause considerable mortality and morbidity following gastrointestinal surgery. Most occur after surgery for malignant, diverticular or inflammatory bowel disease; fewer patients with these conditions develop fistulas spontaneously. Care is often long and costly1, although spontaneous closure can occur with non-operative management in 60–75 per of patients2. The goals of...

ルタテラⓇ静注は、ソマトスタチン受容体（SSTR）陽性の神経内分泌腫瘍（NET）の治療における国内初となるペプチド受容体放射性核種療法の放射性医薬品である。本剤は放射性ルテチウム177（177Lu）で標識されたソマトスタチンアナログであり、静脈から投与後、ソマトスタチン受容体に結合し、腫瘍細胞内に取り込まれ、177Luから放出されるベータ線がDNA損傷を惹起し、細胞増殖抑制作用を発揮する。海外第Ⅲ相試験NETTER-1では、SSTR陽性の切除不能または遠隔転移を有する中腸NET患者を対象として、有効性および安全性が確認され、2017年9月に欧州31カ国において承認を取得し、その後、米国、カナダ、韓国、台湾等で承認を受けた。日本では、SSTR陽性の切除不能または遠隔転移を有する膵、消化管または肺NET患者を対象とした国内第Ⅰ/Ⅱ相試験にて有効性および安全性が確認され、2021年6月に承...

AIMS Acoustic neuroma is a benign tumour, which develops through an overproliferation of Schwann cells along the vestibular nerve. Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five membrane bound receptor subtypes. The aim of this study was to determine whether somatostatin receptor subtypes (SSTRs) 1, 2, 3, and 5 are present in ac...

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) represent a heterogenous group of tumors arising from a variety of neuroendocrine cell types. The incidence and prevalence of GEP-NENs have markedly increased over the last three decades. Symptoms are often absent in early disease, or vague and nonspecific even in advanced disease. Delayed diagnosis is thus common. Chromogranin A is the...

Background. Somatostatin receptors (SSTRs) are over-expressed in several tumors making it possible for imaging with labelled SSTR. A previous study showed feasibility to image oesophageal cancer with SSTR analogue (99m)Tc-depreotide. Purpose. (1) To investigate expression of the SSTRs in different types of esophageal carcinoma and (2) to correlate such an expression with (99m)Tc-depreotide upta...

Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that can involve virtually all organ systems. Whereas most patients present without symptoms, progressive and disabling organ failure can occur in up to 10% of subjects. Somatostatin receptor (SSTR)-directed peptide receptor radionuclide therapy (PRRT) has recently received market authorization for treatment of SSTR-positiv...