BACKGROUND There have been few studies describing wound infiltration with additional intraarticular administration of multimodal analgesia for total knee arthroplasty (TKA). In this study, we assessed the efficacy of wound infiltration combined with intraarticular regional analgesia with epidural infusion on analgesic requirements and postoperative pain after TKA. METHODS 40 consecutive patie...

BACKGROUND Nowadays, increasingly more preemptive analgesia studies focus on postoperative pain; however, the impact of preemptive analgesia on perioperative opioid requirement is not well defined. This study was carried out in order to evaluate whether preoperative intravenous flurbiprofen axetil can reduce perioperative opioid consumption and provide postoperative analgesia in patients underg...

BACKGROUND This study tested the hypothesis that an injectable cyclooxygenase (COX)-2-specific inhibitor will be at least as effective and well tolerated as a COX-nonspecific conventional nonsteroidal antiinflammatory drug (NSAID) by comparing the analgesic efficacy and tolerability of one intravenous dose of parecoxib sodium, an injectable prodrug of the novel COX-2-specific inhibitor, valdeco...

Abstract Background Perioperative pain management following cervical rib excision can be compounded in the background of chronic disorder caused by neurovascular compression. The former mandates an enhanced analgesic requirement wherein perioperative opioid use, particular, associated with a peculiar adverse-effect profile and abuse potential. Appropriate to context, opioid-free anesthesia (OFA...

OBJECTIVE To assess the use of analgesia in an accident and emergency (A&E) department and identify shortcomings. SETTING University teaching hospital. METHODS An audit of patients referred from the A&E department to orthopaedic fracture clinic (n = 100) or for orthopaedic admission (n = 100) was carried out to document analgesia use. An analgesia protocol was introduced and analgesia use w...

conclusions this study demonstrated improved analgesic effects after using intravenous patient controlled analgesia with ketamine on postoperative pain in opium abusers. patients and methods after institutional review board approval for ethical considerations, a randomized double-blinded placebo controlled clinical trial was conducted. a total of 140 male patients aged 18-65 years, undergoing o...

In a double-blind study of on-demand intravenous analgesia buprenorphine was found to be about 600 times as potent as pethidine. The incidence of side effects was similar with both drugs. The quality of analgesia, subjectively assessed, was good with both drugs using this method of administration. Provided that its low potential for abuse is substantiated, buprenorphine appears to be a powerful...

A retrospective chart review was conducted of patients with acute renal colic for the years 1993 and 1997, in order to compare analgesia ordering and administration practices before and after implementation of a nurse-managed, titrated intravenous (i.v.) narcotic policy. The study demonstrated a significant and sustained change in analgesia administration practices away from the intramuscular (...