conclusions the addition of 2.5-3 mcg sufentanil to 15 mg 0.05% bupivacaine maintained the patient’s hemodynamic stability similar to fentanyl. intrathecal sufentanil added to bupivacaine,when compared with fentanyl, may lead to prolonged duration of analgesia, facilitate the spread of the sensory block, increase mean spo2 levels, and reduce overall side effects. background the addition of intr...

BACKGROUND Dystonic cerebral palsy is primarily caused by damage to the basal ganglia and central cortex. The daily care of these patients can be difficult due to dystonic movements. Intrathecal baclofen treatment is a potential treatment option for dystonia and has become common practice. Despite this widespread adoption, high quality evidence on the effects of intrathecal baclofen treatment o...

Intrathecal drug delivery is an effective pain management option for patients with chronic and cancer pain. The delivery of drugs into the intrathecal space provides superior analgesia with smaller doses of analgesics to minimize side effects while significantly improving quality of life. This article aims to provide a general overview of the use of intrathecal drug delivery to manage pain, dos...

Intrathecal pump system implies that the medication is administered directly into the central nervous system, which potentially reduces the side effects. Previous studies comparing the efficacy of intrathecal pump in association with medical management alone showed that at 4 weeks follow-up, 84.5% of patients in the intrathecal treatment group had clinical success vs. 70.8% in the conventional ...

Background: Anticholinesterases increase the concentration of acetylcholine at the postsynaptic sites which cause prolonged analgesia. Aims Objectives: To evaluate and compare the effects of intrathecal neostigmine and intrathecal fentanyl on post-operative pain relief. Materials and Methods: After informed consent, 60 female patients of age between 40 and 60 years, belonging to ASA Grades 1 an...

Quantitative and qualitative techniques for assessment of the intrathecal humoral immune response in human African trypanosomiasis were compared, and their diagnostic potential for detection of the meningo-encephalitic stage of the disease was evaluated. Total and trypanosome specific immunoglobulin G (IgG) and IgM intrathecal synthesis were studied in paired cerebrospinal fluid (CSF) and blood...

BACKGROUND The analgesic mechanisms of cyclooxygenase (COX)-2 inhibitors have been explained mainly on the basis of the inhibition of prostaglandin biosynthesis. However, several lines of evidence suggest that their analgesic effects are mediated through serotonergic or adrenergic transmissions. We investigated the roles of these neurotransmitters in the antinociception of a selective COX-2 inh...

OBJECT Intrathecally delivered baclofen has been used as a treatment for severe spasticity since 1984. Despite this, there are uncertainties surrounding the benefits of treatment and the costs involved. The authors assessed the evidence of benefits and identified costs and the cost/benefit ratio for continuous intrathecal baclofen infusion in the treatment of severe spasticity. METHODS A syst...

When isoniazid is used for the chemotherapy of tuberculous meningitis the need for intrathecal therapy is controversial. A Scottish Joint Committee (1957) concluded from a comparative trial, including both adults and children, that intrathecal streptomycin is not now an essential part of the treatment. But, in fact, all the patients reported did receive intrathecal streptomycin for at least one...

Intrathecal morphine is often used for postoperative analgesia after surgery. We performed a meta-analysis to obtain more detailed information on the frequency of side-effects in patients receiving intrathecal morphine in combination with spinal anaesthesia compared with placebo treated patients. We clustered the analysis to patients receiving placebo, less than morphine 0.3 mg (M < 0.3), or eq...