n engl j med 369;10 nejm.org september 5, 2013 889 20 to 30 minutes of ischemia, it takes several hours for transmural myocardial necrosis to develop. The goal of reperfusion therapy with fibrinolytic drugs or primary percutaneous coronary intervention (PCI) is to restore blood flow to ischemic, but still viable, myocardium and reduce infarct size. Reducing the time to treatment and maximizing ...

Thrombolytic therapy has become standard care in treating acute myocardial infarction. Fibrinolytic drugs such as streptokinase, APSAC and urokinase are non fibrin specific, and induce systemic activation of the fibrinolytic process, while t-PA and prourokinase are fibrin specific since they are able to activate mainly fibrin bound plasminogen. Both groups of thrombolytics exert different and o...

to review our experience in treatment of patients with thoracic empyema at a teaching hospital chart of patients were retrospectively reviewed over a 72-month period. a total of 112 patients (94 men, 18 women, mean age: 39, range: 6-89 years) underwent therapeutic procedures for thoracic empyema between 2001-2006. the causes of empyema included parapneumonic empyema (60.7%), thoracic trauma (20...

Empyema thoracis causes high mortality, and its incidence is increasing in both children and adults. Parapneumonic effusions (PPEs) develop in about one-half of patients hospitalized with pneumonia, and their presence increases mortality by about four-fold. PPEs can be divided into simple PPEs, complicated PPEs, and frank empyema. Two guideline statements on the management of PPEs in adults hav...

abstract introduction the main function of the fibrinolytic system is to dissolve fibrin clots in circulation. this system is composed of inactive precursor plasminogen which can be converted into plasmin by the proteolytic enzymes like tissue-type plasminogen activator (tpa). fibrinolytic properties can be found in a variety of medicine plants and they could effectively prevent cardiovascular ...

Bacterial fibrinolytic enzymes find great applications to treat and prevent cardiovascular diseases. The novel fibrinolytic enzymes from food grade organisms are useful for thrombolytic therapy. This study reports fibrinolytic enzyme production by Bacillus sp. IND7 in solid-state fermentation (SSF). In this study, cow dung was used as the cheap substrate for the production of fibrinolytic enzym...