نتایج جستجو برای: intraperitoneal bupivacaine

تعداد نتایج: 23477  

Journal: :British journal of anaesthesia 1993
D W Cooper G Turner

We have assessed the effect of combining extradural bupivacaine and fentanyl in 60 orthopaedic patients who received 0.125% bupivacaine (bupivacaine group), fentanyl 5 micrograms ml-1 (fentanyl group), or 0.125% bupivacaine combined with fentanyl 5 micrograms ml-1 (combined group), delivered by patient-controlled extradural analgesia for 24 h via a lumbar extradural catheter. Adding bupivacaine...

2014
Lei Huang Fumio Kondo Misako Harato Guo-Gang Feng Naoshisa Ishikawa Yoshihiro Fujiwara Shoshiro Okada

The family of WD repeat proteins comprises a large number of proteins and is involved in a wide variety of cellular processes such as signal transduction, cell growth, proliferation, and apoptosis. Bupivacaine is a sodium channel blocker administered for local infiltration, nerve block, epidural, and intrathecal anesthesia. Recently, we reported that bupivacaine induces reactive oxygen species ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
M Gantenbein L Attolini B Bruguerolle P H Villard F Puyoou A Durand B Lacarelle J Hardwigsen Y P Le-Treut

Bupivacaine is used to provide prolonged anesthesia and postoperative analgesia. The human cytochrome P450 (CYP) involved in bupivacaine degradation into pipecolylxylidine (PPX), its major metabolite, has, to our knowledge, never been described. Microsome samples were prepared from six human livers and incubated in the presence of bupivacaine. The concentrations of PPX in the microsomal suspens...

Journal: :British journal of anaesthesia 1990
A Bodenham G R Park

Bilateral intercostal nerve blocks were performed on 12 occasions in 11 patients after liver transplantation. Group 1 (six patients) received bupivacaine 2 mg kg-1 on one occasion; in group 2 (five patients) bupivacaine 2 mg kg-1 with adrenaline 1:200,000 was injected on two occasions separated by 6 h. Arterial blood was sampled repeatedly and analysed for total bupivacaine concentrations by hi...

Journal: :Anesthesia and analgesia 2005
Marko D Burmester Klaus-Dieter Schlüter Jürgen Daut Peter J Hanley

The main concern with the use of the long-acting local anesthetics bupivacaine and ropivacaine is inadvertent IV injection, which exposes the heart to toxic drug concentrations. We tested the hypothesis that these chiral anesthetics exert enantioselective actions on coronary vascular tone, the regulation of which does not involve voltage-gated Na(+) channels. Coronary perfusion pressure (CPP) w...

Journal: :Investigative ophthalmology & visual science 1993
L K McLoon J Wirtschafter

PURPOSE This study examined the subacute myotoxic effects of injection of the local anesthetic bupivacaine on the orbicularis oculi muscle in the rabbit eyelid. In contrast to other muscles, the orbicularis oculi was resistant to injury by the usual anesthetic doses of bupivacaine when local infiltration is used. An attempt was made to assess the sensitivity of orbicularis oculi muscle to bupiv...

2015
Seong-Ho Ok Hyo-Jin Byon Seong-Chun Kwon Jungchul Park Youngju Lee Yeran Hwang Jiseok Baik Mun-Jeoung Choi Ju-Tae Sohn

Lipid emulsions are widely used for the treatment of systemic toxicity that arises from local anesthetics. The goal of this in vitro study was to examine the cellular mechanism associated with the lipid emulsion-mediated attenuation of vasodilation induced by a toxic dose of bupivacaine in isolated endothelium-denuded rat aorta. The effects of lipid emulsion on vasodilation induced by bupivacai...

Journal: :British journal of anaesthesia 1974
T N Appleyard A Witt R E Atkinson A D Nicholas

Carbonated bupivacaine, plain bupivacaine hydrochloride, and bupivacaine hydrochloride with adrenaline were used to provide epidural analgesia for patients undergoing vaginal hysterectomy. Following injection to the blood concentrations of bupivacaine were measured at intervals over a period of 30 minutes. All three preparations produced satisfactory analgesia at a bupivacaine dose of 1.5 mg/kg...

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