Although it has long been hypothesized that allergen immunotherapy inhibits allergy, in part, by inducing production of IgG Abs that intercept allergens before they can cross-link mast cell Fc epsilonRI-associated IgE, this blocking Ab hypothesis has never been tested in vivo. In addition, evidence that IgG-allergen interactions can induce anaphylaxis by activating macrophages through Fc gammaR...

Idiopathic anaphylaxis is characterized by recurrent anaphylaxis without a known trigger. The coexistence of acute liver injury with idiopathic anaphylaxis is rare, even in cases of severe anaphylaxis such as shock. An unusual case involving repeated episodes of anaphylactic shock accompanied by acute liver injury is described here. A 36-year-old woman who experienced anaphylaxis due to an unkn...

The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis provide a unique global perspective on this increasingly common, potentially life-threatening disease. Recommendations made in the original WAO Anaphylaxis Guidelines remain clinically valid and relevant, and are a widely accessed and frequently cited resource. In this 2015 update of the evidence su...

Aprotinin is a 6512-dalton bovine peptide antifi brinolytic agent. Due to its inhibitory effect on proteolytic enzymes (trypsin, plasmin, kallikrein), it is used to reduce blood loss and transfusion requirements and to limit the systemic infl ammatory response in major surgery under extracorporeal circulation (cardiac surgery, lung and liver transplantation, hip replacement). The frequency of a...

We estimated the influence of acute glucagon applications on (3)H-histamine uptake by the isolated guinea-pig heart, during a single (3)H-histamine passage through the coronary circulation, before and during anaphylaxis, and the influence of glucagon on level of histamine, NO, O2 (-), and H2O2 in the venous effluent during anaphylaxis. Before anaphylaxis, glucagon pretreatment does not change (...

INTRODUCTION Surgical patients are exposed to multiple foreign substances in the perioperative period including drugs, blood products, or environmental antigens such as latex. Because any substance can produce an allergic or adverse reaction, clinicians must be ready to manage patients in this perioperative environment. The most life-threatening form of an allergic reaction is anaphylaxis, howe...

BACKGROUND Anaphylaxis is a potentially fatal condition requiring immediate resuscitation. Data regarding the epidemiology of anaphylaxis are limited and inconsistent. A reason for the variability was unavailability of a universally acceptable case definition till 2005. We reviewed cases using this new definition AIM To review the incidence, clinical presentation, cause and outcome of anaphyl...

PURPOSE Differences in definitions of the condition, relevant triggers, and the geographical locations of study centers, cause estimates of the prevalence of anaphylaxis to vary. Recent epidemiological data indicate that the incidence of anaphylaxis is rising. METHODS To investigate the causes and clinical features of anaphylaxis in Korean adults, factors associated with the severity of the c...

Radiocontrast material is among the common drugs causing allergic reaction. Mostly it well tolerated. The symptoms range from mild with urticaria to fatal anaphylaxis, developing rapidly. Anaphylaxis most severe form of radiocontrast media (RCM) induced hypersensitivity With more use diagnostic and therapeutic procedure, increasing. We report here two cases anaphylactic reaction that occurred d...