Intraocular metastatic tumor is the commonest intraocular malignancy in adults, with uveal tract the commonest site. In nearly 85% of cases the choroid is the afflicted site due to its vascularity. Breast and lung are the common primaries. In breast primaries, this could be the first metastatic disease. This condition should always be kept in mind in patients with visual symptoms. Fundus examin...

purpose: to report a case of unilateral severe visual loss and bilateral optic disc cupping secondary to brain metastasis of bronchogenic carcinoma patient and findings: a 48 year-old woman presented with severe visual loss of left eye without redness or pain or any systemic findings .clinical findings included decreased visual acuity of left eye to 4 m cf and (+3) positive marcus-gunn reflex ....

Intraocular tumors are rare in the dog. Of the reported neoplasms, melanomas are the most common. These tumors characteristically arise in the anterior uvea and secondarily infiltrate posteriorly into the choroid and/ or anteriorly into the corneoscleral region. Advanced tumors may extend extraocularly. In the dog, isolated choroidal melanomas are extremely uncommon; to the authors' knowledge, ...

To study the clinical presentation and treatment outcome among children in South Western China with retinoblastoma (RB) and to determine factors predictive of poor outcome.A retrospective review of children diagnosed with RB from 2006 to 2015 at West China Hospital was undertaken. Demographic and clinical characteristics and treatment outcomes were studied.A total of 253 patients (unilateral 80...

optical rehabilitation of the patient with aphakia who cannot tolerate contact lenses present a therapeutic challenge. in the absence of capsular support, anterior chamber lenses have been widely used. on the other hand intraocular lens implantation of scleral sutured posterior chamber intraocular lens during penterating keratoplasty or insufficient iris support is recommended. the purpose of t...

PURPOSE The aim is to study the clinicodemographic profile and treatment outcome of ocular surface squamous neoplasia (OSSN). METHODS This was a retrospective observational study of 57 eyes (56 cases) with clinically diagnosed OSSN, presenting in our center over the past year. RESULTS The median age of presentation was 55 years with male:female ratio being 4.5:1. Systemic predisposing condi...

PURPOSE Injection of tumor cells transformed by the early region 1 of human adenovirus type 5 (Ad5E1) in the anterior chamber (AC) of C57BL/6 mice leads to intraocular tumor formation. This tumor disappears spontaneously 3 to 4 weeks after tumor inoculation without damaging the neighboring ocular tissues. Previous studies have shown that CD4+ T cells, IFNgamma, and TRAIL (tumor necrosis factor-...

Background: Cataract surgery is one of the most common surgeries in the world, especially in elderly patients, and often performed topically with sedative agents. Ketamine is one of the most commonly used agents and the effect of different doses on intraocular pressure is in dispute. The present study investigates the effect of a low dose of ketamine on intraocular pressure in patients undergoi...

PURPOSE To characterize, in detail, tumor development, malignant cell dissemination, and metastasis in a 10-week animal model of uveal melanoma. METHODS One million 92.1 human primary uveal melanoma cells were injected into the suprachoroidal space of the right eye of 27 immunosuppressed albino rabbits. Intraocular tumor growth was monitored weekly by fundoscopy and by ultrasonography at the ...

purpose: to evaluate the results of combined chemotherapy and periocular carboplatin injection to control advanced intraocular retinoblastoma (rb). methods: in this prospective interventional case-series, we included 8 eyes of 8 patients with advanced intraocular rb (group c or d in international intraocular retinoblastoma classification, iirc). in these patients, periocular carboplatin was inj...