In order to prevent central nervous system (CNS) involvement and improve the prognosis of primary intraocular lymphoma (PIOL), we prospectively evaluated the efficacy of combined therapy using intravitreal methotrexate (MTX) and systemic high-dose MTX on treatment-naïve PIOL. Patients with newly diagnosed PIOL whose lymphoma was limited to the eyes were enrolled. The patients were treated with ...

Study sample Power calculations to determine the sample size were performed (apparently in the preliminary phase of the study). These suggested that a sample of 99 patients in each group was required to detect a 0.4 difference in mean scores between the two groups with 80% power and at a 5% level of significance. All of the patients who underwent bilateral implantation of the multifocal IOL wer...

We propose a complete methodology to develop custom monofocal Intraocular Lens (IOL) designs and evaluate their performance on-axis based on an analytical formulation. The analytical formulation was based on Gaussian and primary aberration theory applied to custom (individual biometric data) and realistic (multilayer cornea and thick IOL) pseudoaphakic eye models. Gradient-based optimization al...

PURPOSE To compare the optical performance of 6 presbyopia-correcting intraocular lenses (IOLs) of different designs (accommodating or multifocal and aspheric or spheric). SETTING Alcon Laboratories, Inc., Fort Worth, Texas, USA. METHODS The optical performance of 6 IOLs were compared using modulation transfer function (MTF) and the United States Air Force 1951 Resolution Target (AFT) testi...

BACKGROUND Intraoperative IOLs clouding of several kinds of hydrophilic acrylic intraocular lenses (IOLs) have been reported due to temperature changes. This phenomenon reported previously occurred in cold countries and during the winter months. However, no clinical case was reported about trifocal IOL opacification during operation. We report a case in which acute opacification of the optical ...

PURPOSE To review published studies reporting the posterior chamber intraocular lens tilt and decentration after surgically uneventful implantation. Potential influences of normally occurring misalignment of modern designs of IOL on the optical performances are discussed. MATERIALS AND METHODS Published theoretical and clinical studies in relation to primarily implanted posterior chamber intr...

A new and complete methodology of monofocal intraocular lens (IOL) design is presented aiming at isoplanatism, i.e. IOLs that provide the eye with optimized optical quality over a wide field of view (typically in a range of ten degrees). The methodology uses a merit function considering dimensional and biomechanical constraints, and a geometrical optical quality metric that is evaluated simulta...

AIMS To compare the quality of vision in pseudophakic patients implanted with aspherical and spherical intraocular lenses (IOLs). MATERIALS AND METHODS Randomized prospective longitudinal intrapatient comparison between aspherical and spherical IOLs performed on 22 patients who underwent bilateral cataract surgery. Best corrected visual acuity, subjective contrast sensitivity, Strehl ratio an...