نتایج جستجو برای: intramyocardial injection
تعداد نتایج: 158478 فیلتر نتایج به سال:
Few data address the role of human mesenchymal stromal cells (MSCs) in the management of chronic ischaemic heart failure. We assessed their effect in immune-deficient animals. MSCs were cultured from bone marrow of human volunteers. Non-obese diabetes severe combined immunodeficiency (NOD/SCID) gamma null mice were randomly assigned to intramyocardial injection of human MSCs or phosphate-buffer...
Despite significant advances in the management of acute myocardial infarction, it remains a major cause of morbidity and mortality. After myocardial infarction, viable myocardi-um is lost and is replaced by fibrotic tissue. This increases the tensile strength of the infarcted myocardium preventing cardiac rupture. However, ultimately it impairs the contractile capacity of the heart leading to h...
AIMS Cell transplantation is a promising approach for patients with myocardial infarction. However, following injection, retention of the transplanted cells in the injected area remains a central issue, which can be deleterious to cell transplantation therapy. We hypothesized that the use of cell sheet fragments, with the preservation of extracellular matrix (ECM), may significantly increase ce...
Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate promising results, many practical and mechanistic issues regarding this therapy remain highly controversial. Here, we report the results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardiomyoplasty. First, cells...
AIMS In clinical studies on cell therapy for acute myocardial infarction (MI), cells are usually applied by intracoronary infusion with balloon (IC/B). To test the utility of balloon occlusion, mononuclear bone marrow cell (MNC) retention after intracoronary infusion without balloon (IC/noB) was compared with IC/B and intramyocardial (IM) injection. METHODS AND RESULTS Four hours after LAD li...
It is well known that the inflammatory protein type IIA secretory Phospholipase A2 (sPLA2-IIA) is involved in the pathogenesis of atherosclerosis. sPLA2-IIA releases fatty acids from membrane phospholipids that form precursors for inflammation inducing eicosanoids. Membrane phospholipids from which sPLA2-IIA has freed a fatty acid are lysophospholipids. These lysophospholipids act as binding si...
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