Cholestasis is a common sequela of liver transplantation. Although the majority of cases remain subclinical, severe cholestasis may be associated with irreversible liver damage, requiring retransplantation. Therefore, it is essential that clinicians be able to identify and treat the syndromes associated with cholestasis. In this review, we consider causes of intrahepatic cholestasis. These may ...

Cholestasis is defined as decrease in bile flow due to impaired secretion by hepatocytes or obstruction of bile flow through intrahepatic or extrahepatic bile ducts. Intrahepatic cholestasis of pregnancy is a condition characterized by pruritis in the second half of pregnancy. It persists until delivery after which it caeses promptly. A genetic background is suggested by family clustering and d...

A potentially dangerous liver condition called intrahepatic cholestasis of pregnancy (ICP) can appear during pregnancy. Primarily manifesting in the third trimester, characteristic symptoms include pruritus (itching) soles and palms, elevated blood bile acid levels, impaired function. Several medications have been demonstrated to significantly improve biochemical indicators gestational age birt...