A general agent theory requires a well-defined domain. We argue that this requirement is not met by most proposed agent theories. The reason is that they are based on assumptions about the internal structure of the agents, often described in terms of human-like “mental states” such as beliefs and intentions. In fact, there are strong indications that the task of developing a general agent theor...

Background In order to achieve drug targeting and controlled release, we have successfully developed a novel drug release system DOX/AuNCs-PM-HA with gold nanocages (AuNCs) as photothermal cores, thermally responsive copolymer P(NIPAM-co-Am) (PM) as the near-infrared (NIR) stimuli gatekeeper and hyaluronic acid as a targeting ligand as well as a capping agent. Methods Cell uptake and cell via...

Controlled drug release systems can offer active agents into living organisms in a programmed manner. These release systems present several advantages. As the first one, they keep constant drug levels in the body, implying a lower drug content to produce the same effect as conventional systems. Besides that, they can preserve the drugs avoiding their destruction by the body. Finally, they can r...

Controlled drug release systems can offer active agents into living organisms in a programmed manner. These release systems present several advantages. As the first one, they keep constant drug levels in the body, implying a lower drug content to produce the same effect as conventional systems. Besides that, they can preserve the drugs avoiding their destruction by the body. Finally, they can r...

Abstract Here, we report the results of experiments regarding chemical repositioning 4‐(2‐hydroxyethyl)‐1‐piperazine ethane sulfonic acid ( HEPES ), a representative buffering agent. In this work, confirmed that could disaggregate amyloid plaques, hallmark Alzheimer's disease, and verified its sustained‐release system (release for up to 2 weeks) via hybridization with biocompatible polymer (Eud...

The development of procedures to enhance drug retention in liposomes is important in order to achieve therapeutically optimized rates of drug release from liposomal carriers. In this study, the ability of lipophilic weak base drugs to complex with arylsulfonates resulting in formation of intravesicular precipitates is investigated as a means to enhance drug retention. It is shown that the aryls...

N,N-Diethyl meta Toluamide (DEET) is an insect repellent agent that contrary to its benefits,if is used in formulations with high skin permeation, will produce side effects of differentseverity. This study attempted to achieve a semi-solid DEET containing formulation withgood appearance, sufficient spreadity, suitable viscosity for tube and jar filling, compatible pHwith skin, reasonable stabil...