نتایج جستجو برای: interleukin 1
تعداد نتایج: 2807174 فیلتر نتایج به سال:
Preexposure to a low dose of interleukin-1 (IL-1; 3 to 30 micrograms/kg) 24 h before a lethal gram-negative bacterial infection prolonged survival in normal and granulocytopenic mice. To examine whether this protective effect is mediated by glucocorticosteroids, we first measured corticosterone concentrations in mice after administration of 80 and 800 ng of IL-1. IL-1 induced a dose-dependent i...
Inflammation is a host defense response to infection that normally culminates in pathogen removal and tissue repair. In the absence of a pathogen, sterile inflammation occurs, which is now recognized as a major contributor to noncommunicable disease (ie, cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes mellitus). Although several regulatory molecules are implicated i...
IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14. Two structural variants of IL-1ra exist: sIL-1ra, a secretory m...
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