OBJECTIVE Closed-loop insulin delivery offers a promising treatment option, but to date, it has only been evaluated in type 1 diabetes. Our aim was to evaluate the feasibility of fully closed-loop subcutaneous insulin delivery in insulin-naïve patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Twelve subjects (seven males, age 57.2 years, BMI 30.5 kg/m2) with noninsulin-treated type 2...

Bypass of the foregut following Roux-en-Y gastric bypass (RYGB) surgery results in altered nutrient absorption, which is proposed to underlie the improvement in glucose tolerance and insulin sensitivity. We conducted a prospective crossover study in which a mixed meal was delivered orally before RYGB (gastric) and both orally (jejunal) and by gastrostomy tube (gastric) postoperatively (1 and 6 ...

OBJECTIVE To comprehensively review the progress to date on the development of alternative routes for insulin delivery. RESEARCH DESIGN AND METHODS Study data were collected through a Medline review. RESULTS Proof of principle has been established for many routes of administration including dermal, nasal, oral, buccal, and pulmonary insulin delivery. CONCLUSIONS Of all the approaches to d...

This prospective, open-label study was designed to measure the impact of short-term infusion-set disconnects on glucose levels. Continuous subcutaneous insulin infusion therapy allows for uninterrupted delivery of insulin. Patients disconnect their insulin pumps from their infusion sets when showering, swimming, exercising, or during intimate moments. Interrupting insulin infusion results in ce...

In the current study hollow microneedles (HMNs) were fabricated by means of vat polymerization method for transdermal delivery insulin. Two geometries HMNs designed in a Computer Aided Design (CAD) software namely, curved pyramid and syringe-like with Liquid Crystal Display (LCD) method. Dimensions determined quality features imaged scanning electron microscopy (SEM). Volumetric characterizatio...

Targeted glycemic control in patients with type 1 and type 2 diabetes is grossly inadequate, despite data demonstrating reduced microvascular and macrovascular diabetic complications with intensive treatment. A significant proportion of individuals with poorly-controlled type 2 diabetes are resistant to initiating treatment with insulin. Several decades-long search for alternative forms of insu...