Background and objectives: The role of genetic components in expression of proteins involved in signaling pathways of fat and carbohydrate metabolism has been well-demonstrated. The aim of this study was to determine effects of high intensity interval training (HIIT) on glucose, insulin, and insulin resistance levels as well as IRS1 expression in gastrocnemius muscle of obese Wistar rats. Meth...

a 7-year-old castrated male german shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. in exploratory laparotomy a small nodular mass was...

conclusions because of increasing prevalence of prediabetes at earlier age, it seems necessary to reconsider the screening age in urban areas and perform the screening in all adults at younger ages. results the prevalence of diabetes was 7.04% (4.52% women, 2.52% men) and the prevalence of prediabetes was 8.58% (5.59% women, 2.98% men). thehighest prevalence of diabetes and prediabetes were obs...

objective: crocinisa saffron constituent with a potent anti-oxidant activity. the present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. materials and methods: diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (stz, 50 mg/kg). thereafter, crocin (5, 10 and 20 mg/kg, i.p.), sub...

rabson-mendenhall syndrome is a rare genetic disorder characterized by growth retardation, dysmorphisms, lack of subcutaneous fat, acanthosis nigricans, enlarged genitalia, hirsutism, dysplastic dentition, coarse facial features, paradoxical fasting hypoglycemia, postprandial hyperglycemia, extreme hyperinsulinemia and pineal hyperplasia. herein, we described a 10- year-old girl with physical f...

objectives: to investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps. materials and methods: in this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (igf-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with a...

objective: stress and cortisol increase blood glucose. considering the role of central catecholaminergic pathways on hypothalamic-pituitary adrenocortical axis, and results of some studies that alprazolam (a benzodiazepine) has inhibitory effect on catecholamines, it seems that alprazolam may reduce blood glucose. the aim of this study was to evaluate the effect of alprazolam on serum insulin l...