General anesthetics have been a mainstay of surgical practice for more than 150 years, but the mechanisms by which they mediate their important clinical actions remain unclear. Ion channels represent important anesthetic targets, and, although GABA(A) receptors have emerged as major contributors to sedative, immobilizing, and hypnotic effects of intravenous anesthetics, a role for those recepto...

Various clinical trials have assessed how intraoperative anesthetics can affect early recovery, hemodynamics and nociception after supratentorial craniotomy. Whether or not the difference in recovery pattern differs in a meaningful way with anesthetic choice is controversial. This review examines and compares different anesthetics with respect to wake-up time, hemodynamics, respiration, cogniti...

It is well known that both local and volatile anesthetics depress myocardial functions. This study was performed to evaluate the combined effects of commonly utilized local anesthetics (bupivacaine, mepivacaine, and lidocaine) and a volatile anesthetic (isoflurane) on heart rate and myocardial contractility in an isolated rat working heart preparation using each local anesthetic at 0 to 3 x 10(...

introduction pharmacologic treatment of radicular pain with oral medications is limited by adverse effects and concern for dependence. while topical formulations have been explored in pain research, there is no published literature evaluating the efficacy in radicular pain. we present the first three cases of radicular pain successfully treated with a topical formulation of diclofenac, ibuprofe...

Local anesthetics are commonly used in the perioperative environment to facilitate surgical procedures or to provide postoperative pain management for patients. The use of local anesthetics, however, introduces the risk of complications resulting from local anesthetic systemic toxicity and the risks of increased morbidity and mortality for the surgical patient. Systemic toxicity from the inject...

PURPOSE Research studies have demonstrated the need for and the ability of dental hygienists to provide local anesthetics for pain control and reduction of patient anxiety. Although two-thirds of state dental practice laws allow these services to be performed by dental hygienists, controversy exists between organized dentistry and dental hygiene regarding the administration of local anesthetics...

Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization ti...

Introduction: Mitochondrial Disorders (1/4,000 patients) are rare and caused by dysfunctional mitochondria. Anesthetic consideration in patients with involves careful preoperative perioperative observations. Objective: To provide a brief insight into how general anesthetics interfere mitochondrial energy formation pathways help form precautions for anesthesiologists when managing Disorder. Revi...