The purpose of this study was to prepare and characterize microspheres loaded by cyclosporine A(CyA)-cyclodextrin (CD) complex. To achieve this goal, PLGA microspheres loaded by CyA CD complex were prepared by multiple emulsificationsolvent evaporation methods.Morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. Microscopic evaluation of mi...

Fibers composed of polysaccharides are a promising candidate to be applied for biomaterials such as absorbable surgical sutures, textile fabrics, and hierarchical three-dimensional scaffolds. In this work, in order fabricate biocompatible fibers with controlled-release abilities, the fabrication coaxial calcium alginate (ALG-Ca) polyion complexes (PICs) consisting chitosan (CHI) chondroitin sul...

Multidrug regimens can sometimes treat recalcitrant diseases when single-drug therapies fail. Recapitulating complex multidrug administration from controlled release films for localized delivery remains challenging because their release kinetics are frequently intertwined, and an initial burst release of each drug is usually uncontrollable. Kinetic control over protein release is demonstrated b...

We evaluated the effect of water storage on fluoride release and mechanical properties of compomer restorative material. Fluoride release was recorded using a specific fluoride electrode. Flexural properties and fracture toughness were measured using a universal testing machine. Vickers hardness was measured using a micro-hardness tester. There was initial burst of fluoride release up to 1 w, w...

Prothionamide (PTH), a second line antitubercular drug is used to administer in conventional oral route. However, its unpredictable absorption and frequent administration limit its use. An alternate approach was thought of administering PTH through pulmonary route in a form of nanoparticles, which can sustain the release for several hours in lungs. Chitosan, a bio-degradable polymer was used to...

Study provides an in-depth analysis of the structure-function relationship polysaccharide anticancer drug carriers and points out benefits potential drawbacks differences in glycosidic bonding, branching binding mode carriers. Cellulose, dextrin, dextran hyaluronic acid have been regioselectively oxidized to respective dicarboxylated derivatives, allowing them directly conjugate cisplatin, whil...

The purpose of this study was to develop freeze dried Polylactide-co-glycolide (PLGA) nanoparticles loaded with etoposide intended be administered intravenously improved therapeutic efficacy the drug and thereby reduced dose related toxicity associated it. were prepared using modified spontaneous emulsification solvent diffusion method (SESD).The in Vitro release (PLGA)–Nanoparticles NP carried...

In studying in vitro drug release from nanoparticles (NPs) an important issue to consider is the method that can be used to measure drug release [1]. The characterization of the in vitro drug release from a colloidal carrier is technically difficult to achive. This can be attributed to the inability of effective and rapid separation of the particles from the dissolved or released drug in the su...

Tachykinin immunoreactivity is found in a ventromedial spinal plexus in the lamprey. Neurons in this plexus project bilaterally and are thus in a position to modulate locomotor networks on both sides of the spinal cord. We have examined the effects of the tachykinin substance P on NMDA-evoked locomotor activity. Brief (10 min) application of tachykinin neuropeptides results in a prolonged conce...

Chitosan/gelatin and chitosan/gelatin/zeolite films prepared by solvent casting method are impregnated with a mixture of thymol carvacrol using green solvent, supercritical carbon dioxide at 35 °C 30 MPa, during 18 h. Proposed enables preparation biocompatible biodegradable blends strong antioxidant antibacterial activity, whereby amounts loaded thymol/carvacrol (TC) in the range from 3.3% to 6...