نتایج جستجو برای: inha inhibition
تعداد نتایج: 328589 فیلتر نتایج به سال:
The natural product Agelasine F found in marine sponge Agelas sp. along with the known inhibitors of the target enzymes in Mycobacterium tuberculosis (Mtb), and the first-line tuberculosis (TB) drugs have been docked to enoyl reductase (InhA), Isoniazid-resistant I21V and S94A enoylACP (COA) reductase mutant enzymes, 7,8-diaminopelargonic acid synthase (DAPAS), pantothenate synthetase (PS), and...
This study aims to evaluate the clinical value of PCR-fluorescent probes for detecting mutation gene associated with extensively drug-resistant tuberculosis (XDR-TB). The molecular species identification 900 sputum specimens was performed using polymerase chain reaction (PCR)–fluorescent probe. mutations drug resistance genes rpoB, katG, inhA, embB, rpsL, rrs, and gyrA were detected. convention...
Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of isoniazid resistance is linked to mutations in the pro-drug activating enzyme KatG, so the discovery of direct inhibitors (DI) of the enoyl-ACP r...
Slow-onset enzyme inhibitors are of great interest for drug discovery programs since the slow dissociation of the inhibitor from the drug-target complex results in sustained target occupancy leading to improved pharmacodynamics. However, the structural basis for slow-onset inhibition is often not fully understood, hindering the development of structure-kinetic relationships and the rational opt...
BACKGROUND The objectives of the study were to compare the performance of line probe assay (GenoType MTBDRplus) with solid culture method for an early diagnosis of multidrug resistant tuberculosis (MDR-TB), and to study the mutation patterns associated with rpoB, katG and inhA genes at a tertiary care centre in north India. METHODS In this cross-sectional study, 269 previously treated sputum-...
BACKGROUND Tuberculosis (TB) incidence and mortality are declining worldwide; however, poor detection of drug-resistant disease threatens to reverse current progress toward global TB control. Multiple, rapid molecular diagnostic tests have recently been developed to detect genetic mutations in Mycobacterium tuberculosis (Mtb) genes known to confer first-line drug resistance. Their utility, thou...
Faculty of Information Technology and systems, Delft University of Technology, Delft, the Netherlands *Department of Automation Engineering, Inha University, Inchon, Korea **Faculty of Electrical Engineering, Fern Universität, Hagen, Germany ***Intelligent Control and Systems Group, School of Electrical and Electronic Engineering, Queen’s University, Belfast, UK ****Department of Electrical and...
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