This perspective on Vogel et al. (beginning on page 696 in this issue of the journal) examines tamoxifen and raloxifene prescription patterns and why these agents are little used for breast cancer prevention despite their effectiveness in definitive trials, Food and Drug Administration approval, and American Society of Clinical Oncology Guidelines Committee endorsement for this purpose. The com...

Most data-based predictive modeling techniques have an inherent weakness in that they may give unstable or inconsistent results when the predictor data is highly correlated. Predictive modeling problems of this design are usually under constrained and are termed ill-posed. This paper presents several examples of ill-posed surveillance and diagnostic problems and regularization methods necessary...

From the perspective of quantum gravity research, since archetypal gravitational object, black hole, was accidentally found function as a thermodynamic system, it is certainly natural to suggest that secret may lie in analysis. Until now, not possible express fine-grained entropy hole using rules gravity. However, holes entropic information formula fills this gap by allowing semi-classical appr...

Measurements of graphs and retrieving structural information complex networks using degree-based network entropy have become an informational theoretical concept. This terminology is extended by the concept Shannon entropy. In this paper, we introduce with having edge weights which are basically redefined Zagreb indices. Some bounds calculated to idealize performance in limiting different kinds...

We develop a formal tool for representing and analyzing informational aspects of robotic tasks, based on the formal concept of 'knowl­ edge.' Specifically, we adopt the notion of knowledge-based protocols from distributed systems, and define the notions of knowledge complexity of a robotic task and knowledge ca­ pability of a robot. The resulting formalism naturally captures previous work in th...

Quarter-power scaling of biological features with body mass is commonly observed in a variety of organisms and is considered a universal law in biology. The origin of the quarter-power scaling law has been proposed to be a universal requirement of a maximized hierarchical network for distributing materials (e.g., oxygen and nutrients) in any organism. We propose a mathematical model for the dev...

The development of systems comprising of hardware and software components has been a complex and demanding task. To handle the informational and architectural complexity inherent to these systems novel development approaches supported by powerful tools are taken. In this paper we present an approach that is based on Uml and the concepts of platform-based design, modeldriven architecture, and co...