PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome is a rare early-onset autoinflammatory disease associated with various hematologic findings, including chronic neutropenia and pancytopenia. We report unique case of PAMI in toddler transfusion-dependent hemolytic anemia, hepatosplenomegaly, failure to thrive, developmental delay, multiple malformations. Because acute i...

Article Laboratory findings in a child with SARS-CoV-2 (COVID-19) multisystem inflammatory syndrome was published on May 1, 2021 the journal Clinical Chemistry and Medicine (CCLM) (volume 59, issue 6).

The concept of a systemic inflammatory response syndrome (SIRS) to describe the complex pathophysiologic response to an insult such as infection, trauma, burns, pancreatitis, or a variety of other injuries came from a 1991 consensus conference charged with the task of developing an easy-to-apply set of clinical parameters to aid in the early identification of potential candidates to enter into ...

A 31 year old woman was hospitalized for evaluation of aortic valve insufficiency and her present cardiac status. Clinical and paraclinical findings strongly suggested the presence of a collagen vascular inflammatory processprecisely, the antiphospholipid antibody syndrome (APS), with systemic lupus erythematosus as the underlying disease.

28 Background: Appendicitis occurs with increased frequency in HIV infected compared to 29 HIV uninfected persons. CMV-related appendicitis specifically presents with typical 30 appendicitis symptoms including surgical abdomen, fever and leukocytosis and may have 31 a more severe course with higher mortality than other types of infective appendicitis. We 32 report the first case of CMV appendic...

The concept of 'Compensatory anti-inflammatory response syndrome' (CARS) was proposed in 1997 by Roger Bone (1941-1997) to qualify the consequences of the counter-regulatory mechanisms initiated to limit the overzealous inflammatory process in patients with infectious (sepsis) or non-infectious systemic inflammatory response syndrome (SIRS). One major consequence of CARS is the modification of ...