The hypothalamic-pituitary-adrenal axis is an essential component for the maintenance of homeostasis following trauma. Major surgical trauma often induces overwhelming inflammatory responses leading to sepsis and organ dysfunction. This study was designed to evaluate the adrenal responses both before and after various degrees of surgical trauma and to determine the incidence of postoperative re...

The aim of this study was to determine the number and state of activity of cytolytic T lymphocytes (CTL) and their precursors (CTL-P) present in vivo during the early stages of viral infection. The local response to lethal infection with rabies virus was used as a model system that is not accessible to analysis by secondary activation in vitro. The local response to alloantigen served as a cont...

This paper analyses the diagnostic utility of interleukins (1, 4, 6) and lipid metabolism products (cholesterol, triacylglycerols, lipoprotein fractions) in subclinical ketosis cows. It was found that serum levels proinflammatory (IL-1 IL-6) anti-inflammatory (IL-4) cows with did not differ from those clinically healthy animals. therefore indicates absence inflammation form ketosis. These data ...

A host of acute phase proteins whose concentrations increase in blood following infection or inflammations are called inflammatory markers. Hundreds of such markers have been identifiedin various infection diseases, but only very few are being measured by clinical laboratories for diagnostic purpose. While established assays for inflammatory markers like hsCRP, Immunoglobins, procalcitonin, TNF...

Type 2 diabetes mellitus (T2D) is a significant global public health problem that has seen substantial increase in the number of affected individuals recent decades. In murine model T2D (db/db), we found several abnormalities, including aberrant intracellular calcium concentration ([Ca2+]i), decreased glucose transport, increased production reactive oxygen species (ROS), elevated levels pro-inf...

The fairly widespread prevalence of CRSwNP along with the lack remedies for curing disease, a variety hypotheses etiology dictate need further study all links in pathogenesis and clinical features course disease. In coming century “biological medicine”, availability high technologies medical genetics makes it possible to reveal individual characteristics most important regulatory systems body, ...

Cellular responses to injury are crucial for complete tissue regeneration, but their underlying processes remain incompletely elucidated. We have previously reported that myeloid-defective zebrafish mutants display apoptosis of regenerative cells during fin fold regeneration. Here, we found that the apoptosis phenotype is induced by prolonged expression of interleukin 1 beta (il1b). Myeloid cel...

Depression is a risk factor for morbidity and mortality, and immune dysregulation may be partially responsible for this link. Proinflammatory cytokines such as interleukin 6 (IL-6) are reliable predictors of quality of life, morbidity, and many causes of mortality. The current study evaluated relationships between depressive symptoms, as assessed by the CES-D, and stress-induced inflammation. T...

The levels of the proinflammatory cytokines interleukin 6 (IL-6) and IL-8, and the anti-inflammatory cytokines IL-10 and IL-13 were studied in child patients with sepsis. The changes of the cytokine inhibitors soluble IL-6 receptor and soluble p75 TNF-alpha receptor were also investigated in the patients' sera. An increase of pro- and anti-inflammatory cytokine levels was demonstrated at the ti...