Prurigo nodularis (PN) is an intensely pruritic, chronic inflammatory skin disease with diffusely distributed hyperkeratotic nodules featuring cutaneous and systemic inflammation. This study investigated the anti-inflammatory properties of nemolizumab, a humanized anti-IL-31RA antibody, by using unbiased plasma proteomics isobaric Tandem Mass Tags® (TMT®) approach to enrich skin-specific protei...

one of the important reasons for death among the worldwide’s population is trauma which is injury or damage to a biological organism caused by physical harm from an external source. after trauma, the immune system and the early inflammatory immune response activation lead to massive injury. trauma causes activation of nearly all components of the immune system; it also activates the neuroendocr...

Initiation of an inflammatory response requires the co-ordinated participation of proteins within a scaffold in the cytosol of responding cells. The scaffold proteins contain members of a newly discovered family of pyrin-domain adaptor proteins that regulate complex assembly for initiation of nuclear factor kappaB and interleukin-1beta signalling. A paper in this issue of the Biochemical Journa...

Under the influence of many factors, such as cytokines or chemokines, macrophages specialize into two subpopulations: pro-inflammatory M1 (classical pathway) anti-inflammatory M2 (alternative pathway). Upon stimulation with bacterial ligand PAM3CSK4 and upon LPS (Lipopolysaccharide), TLR (toll-like receptors) 1/2 receptors TLR4, respectively, activate NFκB pathway, which leads to downregulation...

background: m2000 is a newly designed and safe non-steroidal anti-inflammatory drug (nsaid). the aim of this study was to assess the effects of m2000 on expression levels of suppressor of cytokine signaling-1 (socs-1) and src homology-2 domain-containing inositol-5’-phosphatase 1 (ship1) proteins via toll-like receptor (tlr) 2/microrna-155 pathway. methods: hek293 tlr2 cell line and peripheral ...

Abstract Vascular inflammation activated by pro-inflammatory cytokines is an inflammatory response that occurs in the early stages of atherosclerosis. Endothelial dysfunction vascular begins with expression cell surface adhesion molecules cytokines. The purpose this study was to evaluate and verify effects isobavachalcone. In study, we investigated isobavachalcone on responses induced tumor nec...

Abstract Background Despite the increased morbidity of ulcerative colitis (UC) in developing countries, available treatments remain unsatisfactory. Therefore, it is urgent to discover more effective therapeutic strategies. Pulsatilla chinensis was widely used for treatment inflamed intestinal diseases including UC thousands years China. Anemoside B4, most abundant triterpenoid saponin isolated ...

N uclear factor (NF)-kB is a key player in the control of both innate and adaptive immunity. NF-kB proteins are present in the cytoplasm in association with inhibitory proteins called inhibitors of kB (IkBs). On activation by a large plethora of inducers, the IkB proteins are phosphorylated, ubiquitinated, and subsequently degraded in the proteasomes. Degradation of IkBs allows translocation of...

   Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. EAE is created in animals by injecting the tissue of myelin basic...

   Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. EAE is created in animals by injecting the tissue of myelin basic...