Objective: To describe the use of large-scale gene expression profiles to distinguish broad categories of myopathy and subtypes of inflammatory myopathies (IM) and to provide insight into the pathogenesis of inclusion body myositis (IBM), polymyositis, and dermatomyositis. Methods: Using Affymetrix GeneChip microarrays, the authors measured the simultaneous expression of approximately 10,000 ge...

Background Idiopathic inflammatory myopathies (IIMs) often lead to severe impairments in quality-of-life related physical and emotional burdens. While the healthcare delivery burden patients with specific types of IIMs has been explored [1] , little is known about caregivers‘ burden, especially rare diseses. [2] Objectives Myositis Support Understanding (MSU), a non-profit patient-led advocacy ...

Skeletal myopathy encompasses both atrophy and dysfunction is a prominent event in cancer chemotherapy-induced cachexia. Here, we investigate the effects of chemotherapeutic agent, 5-fluorouracil (5FU), on skeletal muscle mass function, whether small-molecule therapeutic candidate, BGP-15, could be protective against chemotoxic challenge exerted by 5FU. Additionally, explore molecular signature...

The objective of this study was to investigate the frequency of autoantibodies to hydroxymethylglutaryl coenzyme A reductase (HMGCR) in systemic sclerosis (SSc) and associations with inflammatory myositis and statin exposure.This was a cross-sectional, multicenter study of 306 subjects from the Canadian Scleroderma Research Group cohort who had complete data on statin exposure and serology for ...